Coa8 cytochrome c oxidase assembly factor 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coa8provided by RGD
Official Full Name: cytochrome c oxidase assembly factor 8provided by RGD
Primary source: RGD:1304719
See related: AllianceGenome:RGD:1304719
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Apop1; APOP-1; Apopt1; RGD1304719
Summary: Predicted to be involved in several processes, including mitochondrial cytochrome c oxidase assembly; positive regulation of cytochrome-c oxidase activity; and protein stabilization. Predicted to act upstream of or within intrinsic apoptotic signaling pathway. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 17. Orthologous to human COA8 (cytochrome c oxidase assembly factor 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 160.1), Kidney (RPKM 155.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (136593399..136618237)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (130772218..130797081)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (136185772..136210936) , (136279476..136304317)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH134587 (e-PCR)
- UniSTS:217867

AA892746 (e-PCR)
- UniSTS:250071

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytochrome-c oxidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in matrix side of mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in matrix side of mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytochrome c oxidase assembly factor 8

Names: UPF0671 protein C14orf153 homolog; apoptogenic 1, mitochondrial; apoptogenic protein 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037769.2 → NP_001032858.1 cytochrome c oxidase assembly factor 8

See identical proteins and their annotated locations for NP_001032858.1

Status: VALIDATED

Source sequence(s)

BC107661, JAXUCZ010000006

UniProtKB/Swiss-Prot

Q32Q90

UniProtKB/TrEMBL

A6KBS9

Conserved Domains (1) summary

pfam10231
Location:54 → 181

DUF2315; Uncharacterized conserved protein (DUF2315)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

136593399..136618237

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261787.1 → XP_063117857.1 cytochrome c oxidase assembly factor 8 isoform X1

UniProtKB/TrEMBL

A0A8I6AB95, A0A8L2R305
XM_063261789.1 → XP_063117859.1 cytochrome c oxidase assembly factor 8 isoform X3
XM_063261788.1 → XP_063117858.1 cytochrome c oxidase assembly factor 8 isoform X2