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Brf1 BRF1 general transcription factor IIIB subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 299347, updated on 27-Nov-2024

Summary

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Official Symbol
Brf1provided by RGD
Official Full Name
BRF1 general transcription factor IIIB subunitprovided by RGD
Primary source
RGD:1311158
See related
EnsemblRapid:ENSRNOG00000014595 AllianceGenome:RGD:1311158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Used to study fibroma. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 90.6), Thymus (RPKM 83.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Brf1 in Genome Data Viewer
Location:
6q32
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137854055..137902629, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (132034378..132081313, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137762230..137808573, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene jagged canonical Notch ligand 2 Neighboring gene nudix hydrolase 14 Neighboring gene BTB domain containing 6 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene uncharacterized LOC134479482 Neighboring gene uncharacterized LOC134479483

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. Johnson SA, et al. J Biol Chem, 2008 Jul 11. PMID 18456653, Free PMC Article
  2. Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Ernens I, et al. Nucleic Acids Res, 2006. PMID 16407335, Free PMC Article
  3. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Angelis E, et al. Circ Res, 2008 May 23. PMID 18420946, Free PMC Article
  4. Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Raineri I, et al. Nucleic Acids Res, 2004. PMID 14976220, Free PMC Article
  5. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase III general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor IIIB 90 kDa subunit
Names
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB
BRF1, RNA polymerase III transcription initiation factor 90 subunit
BRF1, RNA polymerase III transcription initiation factor subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399505.1 → NP_001386434.1  transcription factor IIIB 90 kDa subunit

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Related
    ENSRNOP00000104047.1, ENSRNOT00000146234.1
    Conserved Domains (2) summary
    COG1405
    Location:4 → 266
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    pfam07741
    Location:449 → 546
    BRF1; Brf1-like TBP-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    137854055..137902629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112104.2 → XP_038968032.1  transcription factor IIIB 90 kDa subunit isoform X1

    UniProtKB/TrEMBL
    A6KBX3, D4A8W8
    Conserved Domains (2) summary
    COG1405
    Location:4 → 266
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    pfam07741
    Location:448 → 545
    BRF1; Brf1-like TBP-binding domain

  2. XM_008764931.4 → XP_008763153.1  transcription factor IIIB 90 kDa subunit isoform X2

    Conserved Domains (3) summary
    COG1405
    Location:10 → 118
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
    pfam07741
    Location:305 → 397
    BRF1; Brf1-like TBP-binding domain
    cl00050
    Location:39 → 112
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  3. XM_017594112.3 → XP_017449601.1  transcription factor IIIB 90 kDa subunit isoform X3

    Conserved Domains (2) summary
    pfam07741
    Location:249 → 341
    BRF1; Brf1-like TBP-binding domain
    cl00050
    Location:3 → 56
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  4. XM_017594111.3 → XP_017449600.1  transcription factor IIIB 90 kDa subunit isoform X3

    Conserved Domains (2) summary
    pfam07741
    Location:249 → 341
    BRF1; Brf1-like TBP-binding domain
    cl00050
    Location:3 → 56
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  5. XM_039112105.2 → XP_038968033.1  transcription factor IIIB 90 kDa subunit isoform X4

    Conserved Domains (1) summary
    COG1405
    Location:4 → 266
    SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106761.1: Suppressed sequence

    Description
    NM_001106761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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