Sirt6 sirtuin 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sirt6provided by RGD
Official Full Name: sirtuin 6provided by RGD
Primary source: RGD:1305216
See related: EnsemblRapid:ENSRNOG00000006393 AllianceGenome:RGD:1305216
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein lysine deacetylase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to peptide hormone stimulus; and post-embryonic cardiac muscle cell growth involved in heart morphogenesis. Predicted to be located in chromosome, subtelomeric region and nucleoplasm. Predicted to be active in chromosome; endoplasmic reticulum; and nucleus. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 55.9), Lung (RPKM 55.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (8733056..8738543)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8082312..8087776)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (10937622..10943048)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic Shock by Inhibiting SIRT6 Expression.
Title: MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic Shock by Inhibiting SIRT6 Expression.
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
Title: Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats.
USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
Title: USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.
Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
Title: Follistatin-like 1 protects against doxorubicin-induced cardiotoxicity by preventing mitochondrial dysfunction through the SIRT6/Nrf2 signaling pathway.
SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats.
Title: SIRT6 Improves Hippocampal Neurogenesis Following Prolonged Sleep Deprivation Through Modulating Energy Metabolism in Developing rats.
Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged.
Title: Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged.
DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo.
Title: DNMT1 regulates polarization of macrophage-induced intervertebral disc degeneration by modulating SIRT6 expression and promoting pyroptosis in vivo.
Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells.
Title: Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells.
Overexpressing SIRT6 can Attenuate the Injury of Intracerebral Hemorrhage by Down-Regulating NF-kB.
Title: Overexpressing SIRT6 can Attenuate the Injury of Intracerebral Hemorrhage by Down-Regulating NF-kB.
SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3).
Title: SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3).

Submit: New GeneRIF Correction See all GeneRIFs (38)

General gene information

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Markers

Sirt6 (e-PCR), detects polymorphism
- UniSTS:531300

RH128538 (e-PCR)
- UniSTS:211846

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA damage sensor activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-arginine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein demyristoylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein depalmitoylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables TORC2 complex binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables histone H3K18 deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone H3K56 deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone H3K9 deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone H3K9 deacetylase activity, hydrolytic mechanism	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone deacetylase regulator activity	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to endothelin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ketone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pericentric heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel branching	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic cardiac muscle cell growth involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein delipidation	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to site of double-strand break	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in subtelomeric heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome, subtelomeric region	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein deacylase sirtuin-6

Names: NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6

NP_001026819.1

EC 2.4.2.31

XP_038934594.1

EC 2.4.2.31

XP_038934595.1

EC 2.4.2.31

XP_038934597.1

EC 2.4.2.31

XP_063119252.1

EC 2.4.2.31

XP_063119253.1

EC 2.4.2.31

XP_063119254.1

EC 2.4.2.31

XP_063119255.1

EC 2.4.2.31

XP_063119256.1

EC 2.4.2.31

XP_063119257.1

EC 2.4.2.31

XP_063119258.1

EC 2.4.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031649.1 → NP_001026819.1 NAD-dependent protein deacylase sirtuin-6

See identical proteins and their annotated locations for NP_001026819.1

Status: PROVISIONAL

Source sequence(s)

BC098923

UniProtKB/TrEMBL

A6K863, F7EVU3, Q4FZY2

Related

ENSRNOP00000008758.4, ENSRNOT00000008758.7

Conserved Domains (1) summary

cd01410
Location:45 → 257

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

8733056..8738543

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263182.1 → XP_063119252.1 NAD-dependent protein deacylase sirtuin-6 isoform X1
XM_063263186.1 → XP_063119256.1 NAD-dependent protein deacylase sirtuin-6 isoform X6
XM_039078669.2 → XP_038934597.1 NAD-dependent protein deacylase sirtuin-6 isoform X8

Conserved Domains (1) summary

cl00195
Location:10 → 210

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_063263183.1 → XP_063119253.1 NAD-dependent protein deacylase sirtuin-6 isoform X2
XM_063263184.1 → XP_063119254.1 NAD-dependent protein deacylase sirtuin-6 isoform X3
XM_039078666.2 → XP_038934594.1 NAD-dependent protein deacylase sirtuin-6 isoform X4

Conserved Domains (1) summary

cd01410
Location:37 → 249

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_039078667.2 → XP_038934595.1 NAD-dependent protein deacylase sirtuin-6 isoform X5

UniProtKB/TrEMBL

A0A8I6APP5

Conserved Domains (1) summary

cd01410
Location:29 → 241

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_063263185.1 → XP_063119255.1 NAD-dependent protein deacylase sirtuin-6 isoform X4

Related

ENSRNOP00000095912.2, ENSRNOT00000119590.2
XM_063263188.1 → XP_063119258.1 NAD-dependent protein deacylase sirtuin-6 isoform X9
XM_063263187.1 → XP_063119257.1 NAD-dependent protein deacylase sirtuin-6 isoform X7