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Nuak1 NUAK family kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299694, updated on 9-Dec-2024

Summary

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Official Symbol
Nuak1provided by RGD
Official Full Name
NUAK family kinase 1provided by RGD
Primary source
RGD:1309956
See related
EnsemblRapid:ENSRNOG00000008061 AllianceGenome:RGD:1309956
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309956
Summary
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cell adhesion; and regulation of cellular senescence. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 126.0), Heart (RPKM 112.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nuak1 in Genome Data Viewer
Location:
7q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (21217729..21289608)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (19330034..19401918)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (25039336..25111118)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479649 Neighboring gene uncharacterized LOC120093542 Neighboring gene uncharacterized LOC134479588 Neighboring gene uncharacterized LOC100910949 Neighboring gene uncharacterized LOC120093543

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats. Mudunuru J, et al. Eur J Drug Metab Pharmacokinet, 2019 Aug. PMID 30701428
  2. A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. Hou X, et al. Oncogene, 2011 Jun 30. PMID 21317932
  3. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Al-Hakim AK, et al. Biochem J, 2008 Apr 15. PMID 18254724
  4. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. Humbert N, et al. EMBO J, 2010 Jan 20. PMID 19927127, Free PMC Article
  5. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Zagórska A, et al. Sci Signal, 2010 Mar 30. PMID 20354225

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A small molecule dual inhibitor of the c-MYC activated kinases ARK5 and CDK4/6, is being developed.
    Title: Effect of Gender on the Pharmacokinetics of ON 123300, A Dual Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NUAK family SNF1-like kinase 1
Names
AMPK-related protein kinase 5
NUAK family, SNF1-like kinase, 1
NP_001100244.1
XP_038934607.1
XP_038934608.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106774.1 → NP_001100244.1  NUAK family SNF1-like kinase 1

    See identical proteins and their annotated locations for NP_001100244.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473960
    UniProtKB/TrEMBL
    A6IFF8, D3ZQN8
    Related
    ENSRNOP00000010636.5, ENSRNOT00000010636.8
    Conserved Domains (2) summary
    smart00220
    Location:56 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14073
    Location:54 → 307
    STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    21217729..21289608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078679.2 → XP_038934607.1  NUAK family SNF1-like kinase 1 isoform X1

    Related
    ENSRNOP00000102810.1, ENSRNOT00000150342.1
    Conserved Domains (1) summary
    cl21453
    Location:1 → 175
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039078680.2 → XP_038934608.1  NUAK family SNF1-like kinase 1 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 21
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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