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Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299802, updated on 27-Nov-2024

Summary

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Official Symbol
Lgr5provided by RGD
Official Full Name
leucine rich repeat containing G protein coupled receptor 5provided by RGD
Primary source
RGD:1307733
See related
EnsemblRapid:ENSRNOG00000004221 AllianceGenome:RGD:1307733
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr49
Summary
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and oocyte differentiation. Predicted to be located in nucleoplasm and trans-Golgi network membrane. Predicted to be active in plasma membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 35.4), Brain (RPKM 16.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lgr5 in Genome Data Viewer
Location:
7q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (52973151..53107964, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51087059..51221882, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58447097..58587787, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc finger, C3H1-type containing Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 42 Neighboring gene MICOS complex subunit Mic10-like Neighboring gene transfer RNA proline (anticodon AGG) 57 Neighboring gene 39S ribosomal protein L50, mitochondrial-like Neighboring gene large ribosomal subunit protein eL19-like Neighboring gene uncharacterized LOC134479871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats. Chen X, et al. Neurochem Res, 2016 Oct. PMID 27339869
  2. Influence of stress factors on intestinal epithelial injury and regeneration. Lee C, et al. Pediatr Surg Int, 2018 Feb. PMID 29018960
  3. Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer. Junttila MR, et al. Sci Transl Med, 2015 Nov 18. PMID 26582901
  4. Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. Snyder JC, et al. J Biol Chem, 2013 Apr 12. PMID 23439653, Free PMC Article
  5. Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin. Femia AP, et al. BMC Cancer, 2013 Feb 1. PMID 23374535, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-6 expression increased in all groups compared to control. Lgr5 expression was up-regulated in cells exposed to a single stressor, but down-regulated when multiple stressors were administered.
    Title: Influence of stress factors on intestinal epithelial injury and regeneration.
  2. that Leucine-rich repeat-containing G-protein coupled receptor 5might be of great significance in CNS pathophysiology after spinal cord injury
    Title: Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats.
  3. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.
    Title: Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer.
  4. Results support LGR-5 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin.
    Title: Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear β-catenin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within epithelial cell proliferation involved in renal tubule morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hair follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 5
Names
G protein-coupled receptor 49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106784.1 → NP_001100254.1  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

    See identical proteins and their annotated locations for NP_001100254.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473960
    UniProtKB/Swiss-Prot
    D4AC13
    UniProtKB/TrEMBL
    A0A8I6ARJ9
    Related
    ENSRNOP00000005814.3, ENSRNOT00000005814.6
    Conserved Domains (6) summary
    smart00013
    Location:33 → 70
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:88 → 372
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:445 → 467
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:68 → 91
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:575 → 820
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    52973151..53107964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263222.1 → XP_063119292.1  leucine-rich repeat-containing G-protein coupled receptor 5 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AC13.1 GenPept UniProtKB/Swiss-Prot:D4AC13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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