U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cct2 chaperonin containing TCP1 subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299809, updated on 27-Nov-2024

Summary

Official Symbol
Cct2provided by RGD
Official Full Name
chaperonin containing TCP1 subunit 2provided by RGD
Primary source
RGD:1359143
See related
EnsemblRapid:ENSRNOG00000021317 AllianceGenome:RGD:1359143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of with a positive effect on scaRNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida and chaperone-mediated protein complex assembly. Predicted to be located in cell body; cytosol; and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 579.9), Heart (RPKM 469.0) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cct2 in Genome Data Viewer
Location:
7q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54578654..54591428, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52692725..52705478, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (60106532..60122779, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093599 Neighboring gene leucine-rich repeat-containing 10 Neighboring gene fibroblast growth factor receptor substrate 2 Neighboring gene uncharacterized LOC120093600

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC94480

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone mediated protein folding independent of cofactor IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone mediated protein folding independent of cofactor ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to Cajal body ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of telomerase RNA localization to Cajal body IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of telomerase RNA localization to Cajal body ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in scaRNA localization to Cajal body IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_positive_effect scaRNA localization to Cajal body ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IEA
Inferred from Electronic Annotation
more info
 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
part_of chaperonin-containing T-complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
part_of zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of zona pellucida receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit beta
Names
CCT-beta
TCP-1-beta
chaperonin containing TCP1, subunit 2 (beta)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005905.1NP_001005905.1  T-complex protein 1 subunit beta

    See identical proteins and their annotated locations for NP_001005905.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083650
    UniProtKB/Swiss-Prot
    Q5XIM9
    UniProtKB/TrEMBL
    A0A8I6GLE7, A6IGR4
    Related
    ENSRNOP00000095994.1, ENSRNOT00000113939.2
    Conserved Domains (1) summary
    cd03336
    Location:11527
    TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    54578654..54591428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078736.2XP_038934664.1  T-complex protein 1 subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLE7
    Related
    ENSRNOP00000029234.5, ENSRNOT00000037946.7
    Conserved Domains (1) summary
    cd03336
    Location:37553
    TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...