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Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299830, updated on 27-Nov-2024

Summary

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Official Symbol
Lrig3provided by RGD
Official Full Name
leucine-rich repeats and immunoglobulin-like domains 3provided by RGD
Primary source
RGD:1561255
See related
EnsemblRapid:ENSRNOG00000007654 AllianceGenome:RGD:1561255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561255
Summary
Predicted to act upstream of or within otolith morphogenesis. Orthologous to human LRIG3 (leucine rich repeats and immunoglobulin like domains 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 61.4), Kidney (RPKM 58.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrig3 in Genome Data Viewer
Location:
7q22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (63701724..63751898)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (61816313..61866275)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (69213098..69263251)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552186 Neighboring gene solute carrier family 16 member 7 Neighboring gene uncharacterized LOC102552637 Neighboring gene uncharacterized LOC102552423 Neighboring gene uncharacterized LOC120093626 Neighboring gene uncharacterized LOC134479599

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression. Yang K, et al. J Cell Biochem, 2019 Oct. PMID 31119777
  2. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression.
    Title: Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC188535

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within otolith morphogenesis ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeats and immunoglobulin-like domains protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432458.1 → NP_001419387.1  leucine-rich repeats and immunoglobulin-like domains protein 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HQQ1, B5DEJ0, G3V8Y2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    63701724..63751898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_216905.11 → XP_216905.5  leucine-rich repeats and immunoglobulin-like domains protein 3

    Related
    ENSRNOP00000030604.5, ENSRNOT00000032786.7
    Conserved Domains (9) summary
    TIGR00864
    Location:416 → 494
    PCC; polycystin cation channel protein
    COG4886
    Location:77 → 337
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:76 → 99
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:147 → 168
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07679
    Location:697 → 784
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:498 → 585
    Ig_3; Immunoglobulin domain
    cd00096
    Location:705 → 708
    Ig; Ig strand A' [structural motif]
    cd05763
    Location:604 → 694
    IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
    cd21340
    Location:268 → 442
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version

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