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Trps1 transcriptional repressor GATA binding 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299897, updated on 4-Jan-2025

Summary

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Official Symbol
Trps1provided by RGD
Official Full Name
transcriptional repressor GATA binding 1provided by RGD
Primary source
RGD:1311883
See related
EnsemblRapid:ENSRNOG00000024998 AllianceGenome:RGD:1311883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including hair follicle development; negative regulation of transcription by RNA polymerase II; and regulation of chondrocyte differentiation. Predicted to act upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; chondrocyte differentiation; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 158.2), Thymus (RPKM 106.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trps1 in Genome Data Viewer
Location:
7q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (83806121..84032609, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (81916668..82142733, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (90085895..90320430, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479727 Neighboring gene uncharacterized LOC134479603 Neighboring gene uncharacterized LOC120093649 Neighboring gene uncharacterized LOC102548590 Neighboring gene uncharacterized LOC102548754

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The atypical GATA protein TRPS1 represses androgen-induced prostate-specific antigen expression in LNCaP prostate cancer cells. van den Bemd GJ, et al. Biochem Biophys Res Commun, 2003 Dec 19. PMID 14680804
  2. Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Momeni P, et al. Nat Genet, 2000 Jan. PMID 10615131
  3. The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. Kaiser FJ, et al. J Biol Chem, 2003 Oct 3. PMID 12885770
  4. Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. Fantauzzo KA, et al. PLoS Genet, 2012. PMID 23133399, Free PMC Article
  5. TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Stinson S, et al. Sci Signal, 2011 Jun 14. PMID 21673316

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in hair follicle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger transcription factor Trps1
Names
trichorhinophalangeal syndrome I homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134837.1 → NP_001128309.1  zinc finger transcription factor Trps1

    See identical proteins and their annotated locations for NP_001128309.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A8I5Y133, A6HRD1
    Related
    ENSRNOP00000096700.1, ENSRNOT00000110775.2
    Conserved Domains (2) summary
    smart00401
    Location:891 → 934
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:895 → 951
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    83806121..84032609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078765.2 → XP_038934693.1  zinc finger transcription factor Trps1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y133, D3ZEM6
    Related
    ENSRNOP00000039913.3, ENSRNOT00000050774.4

  2. XM_039078762.2 → XP_038934690.1  zinc finger transcription factor Trps1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y133
    Related
    ENSRNOP00000083606.2, ENSRNOT00000106247.2
    Conserved Domains (1) summary
    cd00202
    Location:910 → 966
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  3. XM_063263244.1 → XP_063119314.1  zinc finger transcription factor Trps1 isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y133, A0A8I5ZWX6
    Related
    ENSRNOP00000110301.1, ENSRNOT00000157182.1

  4. XM_039078768.2 → XP_038934696.1  zinc finger transcription factor Trps1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y133
    Related
    ENSRNOP00000077022.1, ENSRNOT00000094294.2

  5. XM_039078760.2 → XP_038934688.1  zinc finger transcription factor Trps1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y133
    Conserved Domains (1) summary
    cd00202
    Location:933 → 989
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  6. XM_039078761.2 → XP_038934689.1  zinc finger transcription factor Trps1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y133
    Related
    ENSRNOP00000110847.1, ENSRNOT00000146817.1

  7. XM_039078767.2 → XP_038934695.1  zinc finger transcription factor Trps1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y133, D3ZEM6

  8. XM_039078764.2 → XP_038934692.1  zinc finger transcription factor Trps1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y133, D3ZEM6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
Nucleotide Protein Strain
Heading Accession and Version

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