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FSCN3 fascin actin-bundling protein 3 [ Homo sapiens (human) ]

Gene ID: 29999, updated on 4-Jan-2025

Summary

Official Symbol
FSCN3provided by HGNC
Official Full Name
fascin actin-bundling protein 3provided by HGNC
Primary source
HGNC:HGNC:3961
See related
Ensembl:ENSG00000106328 MIM:615800; AllianceGenome:HGNC:3961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly; cell migration; and establishment or maintenance of cell polarity. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including lamellipodium; microvillus; and ruffle. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis (RPKM 43.5) See more
Orthologs
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Genomic context

See FSCN3 in Genome Data Viewer
Location:
7q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (127593736..127602144)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (128905415..128913829)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127233790..127242198)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375490 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:127223080-127224279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127224999-127225998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127227286-127227912 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:127227913-127228538 and GRCh37_chr7:127228539-127229165 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127229166-127229791 Neighboring gene uncharacterized LOC105375489 Neighboring gene GRIP and coiled-coil domain containing 1 Neighboring gene ARF GTPase 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:127249495-127249995 Neighboring gene PAX4 5' regulatory region Neighboring gene paired box 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:127291844-127292462 Neighboring gene SND1 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ARF5

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
fascin-3
Names
fascin actin-bundling protein 3, testicular
fascin homolog 3, actin-bundling protein, testicular
testicular secretory protein Li 18
testis fascin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020369.3NP_065102.1  fascin-3

    See identical proteins and their annotated locations for NP_065102.1

    Status: VALIDATED

    Source sequence(s)
    AC073934, AF281049, BC035606
    Consensus CDS
    CCDS34746.1
    UniProtKB/Swiss-Prot
    A4D0Z2, A6NLL7, B2RA62, B4DU68, Q9NQT6
    UniProtKB/TrEMBL
    A0A140VK18
    Related
    ENSP00000265825.5, ENST00000265825.6
    Conserved Domains (2) summary
    cd00257
    Location:386498
    Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
    pfam06268
    Location:271381
    Fascin; Fascin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    127593736..127602144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    128905415..128913829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)