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Ift27 intraflagellar transport 27 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300062, updated on 4-Jan-2025

Summary

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Official Symbol
Ift27provided by RGD
Official Full Name
intraflagellar transport 27provided by RGD
Primary source
RGD:1308703
See related
EnsemblRapid:ENSRNOG00000006440 AllianceGenome:RGD:1308703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rabl4
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including intraciliary transport; smoothened signaling pathway; and spermatogenesis. Predicted to act upstream of or within cochlea development and inner ear receptor cell stereocilium organization. Predicted to be located in centrosome; nucleus; and sperm flagellum. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi membrane and cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 19. Orthologous to human IFT27 (intraflagellar transport 27). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 144.4), Thymus (RPKM 78.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift27 in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111619145..111635129, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109738622..109754416, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119393384..119409710, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 2 Neighboring gene uncharacterized LOC102554213 Neighboring gene parvalbumin Neighboring gene neutrophil cytosolic factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intraflagellar transporter protein (IFT27), an IFT25 binding partner, is essential for male fertility and spermiogenesis in mice. Zhang Y, et al. Dev Biol, 2017 Dec 1. PMID 28964737, Free PMC Article
  2. Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development. Desai PB, et al. Mech Dev, 2018 Jun. PMID 29626631, Free PMC Article
  3. IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment. Eguether T, et al. Dev Cell, 2014 Nov 10. PMID 25446516, Free PMC Article
  4. Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. May-Simera HL, et al. Development, 2015 Feb 1. PMID 25605782, Free PMC Article
  5. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Howard PW, et al. Exp Cell Res, 2013 Aug 15. PMID 23810713, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cochlea development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 27 homolog
Names
RAB, member of RAS oncogene family-like 4
NP_001123967.1
XP_038934762.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130495.1 → NP_001123967.1  intraflagellar transport protein 27 homolog

    See identical proteins and their annotated locations for NP_001123967.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A8I5ZYK4, A0A9K3Y729, B4F765, E9PSL5
    Conserved Domains (2) summary
    pfam00071
    Location:7 → 173
    Ras; Ras family
    cl21455
    Location:6 → 172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    111619145..111635129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078834.2 → XP_038934762.1  intraflagellar transport protein 27 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYK4
    Related
    ENSRNOP00000008450.6, ENSRNOT00000008450.7
    Conserved Domains (1) summary
    cl38936
    Location:6 → 171
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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