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Eif3l eukaryotic translation initiation factor 3, subunit L [ Rattus norvegicus (Norway rat) ]

Gene ID: 300069, updated on 27-Nov-2024

Summary

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Official Symbol
Eif3lprovided by RGD
Official Full Name
eukaryotic translation initiation factor 3, subunit Lprovided by RGD
Primary source
RGD:1308230
See related
EnsemblRapid:ENSRNOG00000011020 AllianceGenome:RGD:1308230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eif3s6ip
Summary
Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation and viral translational termination-reinitiation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Predicted to be active in synapse. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 488.1), Kidney (RPKM 431.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif3l in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112522222..112544063)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110652565..110663614)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120320547..120331596)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene galanin receptor 3 Neighboring gene ankyrin repeat domain 54 Neighboring gene transfer RNA valine (anticodon AAC) 17 Neighboring gene MICAL-like 1 Neighboring gene similar to human chromosome 22 open reading frame 23 Neighboring gene RNA polymerase II, I and III subunit F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA. Powell ML, et al. PLoS One, 2011 Feb 8. PMID 21347434, Free PMC Article
  2. PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. Seither P, et al. Biol Chem, 2001 Aug. PMID 11592397
  3. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181
  4. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Lee AS, et al. Nature, 2015 Jun 4. PMID 25849773, Free PMC Article
  5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Damoc E, et al. Mol Cell Proteomics, 2007 Jul. PMID 17322308

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC116337

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in viral translational termination-reinitiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit L
Names
eukaryotic translation initiation factor 3, subunit 6 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034134.2 → NP_001029306.2  eukaryotic translation initiation factor 3 subunit L

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HSP6, G3V7G9, Q498D2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112522222..112544063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263318.1 → XP_063119388.1  eukaryotic translation initiation factor 3 subunit L isoform X1

    Related
    ENSRNOP00000014817.6, ENSRNOT00000014817.8

  2. XM_063263319.1 → XP_063119389.1  eukaryotic translation initiation factor 3 subunit L isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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