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Cerk ceramide kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 300129, updated on 27-Nov-2024

Summary

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Symbol
Cerkprovided by RGD
Full Name
ceramide kinaseprovided by RGD
Primary source
RGD:1305019
See related
EnsemblRapid:ENSRNOG00000017022 AllianceGenome:RGD:1305019
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ceramide kinase activity and magnesium ion binding activity. Predicted to be involved in ceramide metabolic process. Predicted to be located in plasma membrane. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 241.1), Brain (RPKM 162.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cerk in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (119105674..119149885, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (117225855..117269436, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (127015162..127058056, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 1 Neighboring gene GRAM domain containing 4 Neighboring gene uncharacterized LOC134479762 Neighboring gene TBC1 domain family, member 22a like Neighboring gene TBC1 domain family, member 22a Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis. Hori M, et al. Biochim Biophys Acta Mol Cell Res, 2020 Jul. PMID 32246947
  2. A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function. Hewson CA, et al. Clin Exp Allergy, 2011 Mar. PMID 21255156
  3. Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells. Mitsutake S, et al. J Biol Chem, 2004 Apr 23. PMID 14769792
  4. Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains. Rovina P, et al. Biochim Biophys Acta, 2009 Oct. PMID 19501188
  5. Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Graf C, et al. Biochem Biophys Res Commun, 2008 Aug 15. PMID 18555012

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis.
    Title: Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis.
  2. We have identified a differential role for ceramide kinase in mast-cell activation
    Title: A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function.
  3. Ceramide kinase has a role as a mediator of calcium-dependent degranulation in mast cells.
    Title: Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ceramide kinase
NP_001128333.1
XP_038934781.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134861.1 → NP_001128333.1  ceramide kinase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    D3Z9Y3
    Related
    ENSRNOP00000022882.4, ENSRNOT00000022882.7
    Conserved Domains (1) summary
    cl01255
    Location:55 → 528
    DAGK_cat; Diacylglycerol kinase catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    119105674..119149885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078853.2 → XP_038934781.1  ceramide kinase isoform X1

    Conserved Domains (1) summary
    cl01255
    Location:216 → 505
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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