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Tuba1c tubulin, alpha 1C [ Rattus norvegicus (Norway rat) ]

Gene ID: 300218, updated on 27-Nov-2024

Summary

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Symbol
Tuba1cprovided by RGD
Full Name
tubulin, alpha 1Cprovided by RGD
Primary source
RGD:1307226
See related
EnsemblRapid:ENSRNOG00000075184 AllianceGenome:RGD:1307226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tuba6
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in membrane raft. Orthologous to human TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 2633.8), Brain (RPKM 2595.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tuba1c in Genome Data Viewer
Location:
7q36
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131636974..132078589)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130192050..130199655)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140716113..140723717)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cyclin T1 Neighboring gene sperm microtubule inner protein 11 Neighboring gene cystatin C, pseudogene 1 Neighboring gene adenylate cyclase 6 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 3 Neighboring gene uncharacterized LOC103692978 Neighboring gene DEAD-box helicase 23 Neighboring gene Rho family GTPase 1 Neighboring gene coiled-coil domain containing 65 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene ARF GTPase 3 Neighboring gene transfer RNA lysine (anticodon UUU) 3 Neighboring gene Wnt family member 10B Neighboring gene Wnt family member 1 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene dendrin Neighboring gene lysine methyltransferase 2D Neighboring gene RHEB like 1 Neighboring gene limb development membrane protein 1-like Neighboring gene ribosomal protein L13, pseudogene 3 Neighboring gene desert hedgehog signaling molecule Neighboring gene tubulin, alpha 1B Neighboring gene ribosomal protein L23a, pseudogene 8 Neighboring gene uncharacterized LOC120093830 Neighboring gene tubulin, alpha 1A Neighboring gene uncharacterized LOC102546594 Neighboring gene peripherin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A revised nomenclature for the human and rodent alpha-tubulin gene family. Khodiyar VK, et al. Genomics, 2007 Aug. PMID 17543498
  2. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, et al. Brain Res, 2003 Oct 10. PMID 14499952
  3. Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Zhao M, et al. Mol Cell Biol, 2009 Mar. PMID 19103752, Free PMC Article
  4. PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. Todd MA, et al. J Proteome Res, 2012 Aug 3. PMID 22720776
  5. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tubulin alpha-1C chain
Names
alpha-tubulin 6
tubulin alpha-1C chain-like
tubulin alpha-6 chain
tubulin, alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011995.1 → NP_001011995.1  tubulin alpha-1C chain

    See identical proteins and their annotated locations for NP_001011995.1

    Status: PROVISIONAL

    Source sequence(s)
    BC078829
    UniProtKB/Swiss-Prot
    Q6AYZ1
    UniProtKB/TrEMBL
    A0A8I6ALV8, A6KCD2
    Related
    ENSRNOP00000109253.1, ENSRNOT00000120720.2
    Conserved Domains (2) summary
    PTZ00335
    Location:1 → 448
    PTZ00335; tubulin alpha chain; Provisional
    cd02186
    Location:2 → 435
    alpha_tubulin; The alpha-tubulin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131636974..132078589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263384.1 → XP_063119454.1  tubulin alpha-1C chain isoform X1

  2. XM_063263383.1 → XP_063119453.1  tubulin alpha-1C chain isoform X1

  3. XM_063263382.1 → XP_063119452.1  tubulin alpha-1C chain isoform X1

  4. XM_063263380.1 → XP_063119450.1  tubulin alpha-1C chain isoform X1

  5. XM_063263381.1 → XP_063119451.1  tubulin alpha-1C chain isoform X1

    Related
    ENSRNOP00000020932.8, ENSRNOT00000020932.9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYZ1.1 GenPept UniProtKB/Swiss-Prot:Q6AYZ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
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Tools
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