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Ttc12 tetratricopeptide repeat domain 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300696, updated on 9-Dec-2024

Summary

Official Symbol
Ttc12provided by RGD
Official Full Name
tetratricopeptide repeat domain 12provided by RGD
Primary source
RGD:1303264
See related
EnsemblRapid:ENSRNOG00000008595 AllianceGenome:RGD:1303264
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Testes (RPKM 87.2), Kidney (RPKM 25.1) and 5 other tissues See more
Orthologs
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Genomic context

See Ttc12 in Genome Data Viewer
Location:
8q23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58696381..58743857, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49799916..49847940, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53770685..53818873, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene dopamine receptor D2 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene uncharacterized LOC102555969 Neighboring gene neural cell adhesion molecule 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Clone Names

  • MGC94947

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004246.2NP_001004246.1  tetratricopeptide repeat protein 12

    See identical proteins and their annotated locations for NP_001004246.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079409
    UniProtKB/TrEMBL
    F7FHS8, Q68FR0
    Related
    ENSRNOP00000011454.6, ENSRNOT00000011454.7
    Conserved Domains (4) summary
    cd00020
    Location:612704
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:105133
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:142172
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:105170
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    58696381..58743857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243004.5XP_006243066.1  tetratricopeptide repeat protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMH4, F7FHS8
    Related
    ENSRNOP00000097363.1, ENSRNOT00000102297.2
    Conserved Domains (4) summary
    cd00020
    Location:631723
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:124152
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:161191
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:124189
    TPR_11; TPR repeat
  2. XM_006243005.5XP_006243067.1  tetratricopeptide repeat protein 12 isoform X2

    See identical proteins and their annotated locations for XP_006243067.1

    UniProtKB/TrEMBL
    F7FHS8, Q68FR0
    Conserved Domains (4) summary
    cd00020
    Location:612704
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00006
    Location:105133
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:142172
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:105170
    TPR_11; TPR repeat