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Lactb lactamase, beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 300803, updated on 4-Jan-2025

Summary

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Official Symbol
Lactbprovided by RGD
Official Full Name
lactamase, betaprovided by RGD
Primary source
RGD:1304788
See related
EnsemblRapid:ENSRNOG00000018081 AllianceGenome:RGD:1304788
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables identical protein binding activity. Predicted to be involved in proteolysis and regulation of lipid metabolic process. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human LACTB (lactamase beta). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 316.9), Liver (RPKM 289.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lactb in Genome Data Viewer
Location:
8q24
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76452679..76469986, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67571504..67587592, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72750174..72766307, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554897 Neighboring gene ribosomal protein S27-like Neighboring gene uncharacterized LOC134480198 Neighboring gene U6 spliceosomal RNA Neighboring gene tropomyosin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Keckesova Z, et al. Nature, 2017 Mar 30. PMID 28329758, Free PMC Article
  2. LACTB is a filament-forming protein localized in mitochondria. Polianskyte Z, et al. Proc Natl Acad Sci U S A, 2009 Nov 10. PMID 19858488, Free PMC Article
  3. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine beta-lactamase-like protein LACTB, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106833.1 → NP_001100303.1  serine beta-lactamase-like protein LACTB, mitochondrial

    See identical proteins and their annotated locations for NP_001100303.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474041
    UniProtKB/TrEMBL
    A6KEZ7, D3ZFJ6
    Related
    ENSRNOP00000024452.4, ENSRNOT00000024452.8
    Conserved Domains (1) summary
    pfam00144
    Location:110 → 527
    Beta-lactamase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    76452679..76469986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766242.4 → XP_008764464.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZR42
    Related
    ENSRNOP00000080609.1, ENSRNOT00000100085.2
    Conserved Domains (1) summary
    pfam00144
    Location:110 → 245
    Beta-lactamase; Beta-lactamase

  2. XM_063265165.1 → XP_063121235.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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