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nme2b.1 NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 30083, updated on 4-Jan-2025

Summary

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Official Symbol
nme2b.1provided by ZNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-000210-32
See related
Ensembl:ENSDARG00000103791 AllianceGenome:ZFIN:ZDB-GENE-000210-32
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nme1; nme2; nm23b; NM23-B; ndpkz1; nme2b1; NDPK-Z1; NM23-Z1
Summary
Enables nucleoside diphosphate kinase activity. Acts upstream of or within GTP biosynthetic process and regulation of angiogenesis. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including digestive system; female organism; gonad; heart; and male organism. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nme2b.1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (48117338..48120315)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (48457539..48460510)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene UTP18 small subunit processome component Neighboring gene NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 Neighboring gene bloodthirsty-related gene family, member 30 Neighboring gene PR domain containing 1b, with ZNF domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins. Feng Y, et al. Arterioscler Thromb Vasc Biol, 2014 Oct. PMID 25147336
  2. The NM23 family in development. Bilitou A, et al. Mol Cell Biochem, 2009 Sep. PMID 19421718
  3. The NME gene family in zebrafish oogenesis and early development. Desvignes T, et al. Naunyn Schmiedebergs Arch Pharmacol, 2011 Oct. PMID 21394481
  4. Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A. Ponnudurai RP, et al. J Proteomics, 2012 Jan 4. PMID 22079245
  5. The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Hippe HJ, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805292, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions.
    Title: Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.
  2. Data show that NDPK B knockdown embryo results in a severe decrease in cardiac contractility.
    Title: The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within GTP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleoside diphosphate kinase A
Names
non-metastatic cells 2, protein (NM23B) expressed in
non-metastatic cells 2b.1, protein (NM23B) expressed in
nucleoside diphosphate kinase-Z1
NP_001349193.1
NP_001349194.1
NP_001349195.1
NP_571001.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362264.1 → NP_001349193.1  nucleoside diphosphate kinase A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    CU694252, EH513618
    UniProtKB/TrEMBL
    A0A8M6Z292, Q9IAD3
    Conserved Domains (1) summary
    PTZ00093
    Location:6 → 163
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  2. NM_001362265.1 → NP_001349194.1  nucleoside diphosphate kinase A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    CU694252
    UniProtKB/TrEMBL
    Q9IAD3
    Conserved Domains (1) summary
    PTZ00093
    Location:6 → 152
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

  3. NM_001362266.1 → NP_001349195.1  nucleoside diphosphate kinase A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    CU694252
    Conserved Domains (1) summary
    cl00335
    Location:1 → 84
    NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

  4. NM_130926.2 → NP_571001.2  nucleoside diphosphate kinase A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    CU694252
    UniProtKB/TrEMBL
    Q9IAD3
    Related
    ENSDARP00000136238.1, ENSDART00000160549.2
    Conserved Domains (1) summary
    PTZ00093
    Location:6 → 152
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    48117338..48120315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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