nme2b.2 NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nme2b.2provided by ZNC
Official Full Name: NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000210-33
See related: Ensembl:ENSDARG00000099420 AllianceGenome:ZFIN:ZDB-GENE-000210-33
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ndpkz2; nme2b2; NDPK-Z2; NM23-Z2
Summary: Enables nucleoside diphosphate kinase activity. Acts upstream of or within GTP biosynthetic process. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including digestive system; eye; female organism; gonad; and male organism. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (48111247..48114446)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (48451507..48454668)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NDPKB is required for VEGF-induced angiogenesis and contributes to the correct localization of VEGF receptor type 2 and VE-cadherin at the endothelial adherens junctions.
Title: Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.
The expression level of NDK-Z2 was upregulated to a greater extent than those for myogenin and myostatin 1 under restricted feeding.
Title: Feeding restriction alters expression of some ATP related genes more sensitively than the RNA/DNA ratio in zebrafish, Danio rerio.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GTP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate kinase B

Names: non-metastatic cells 2b.2, protein (NM23B) expressed in; nucleoside diphosphate kinase-Z2

NP_571002.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130927.2 → NP_571002.1 nucleoside diphosphate kinase B

See identical proteins and their annotated locations for NP_571002.1

Status: VALIDATED

Source sequence(s)

CU694252, EH432412

UniProtKB/TrEMBL

A0A8M1P6C6, Q7SXL4

Related

ENSDARP00000135769.1, ENSDART00000169420.2

Conserved Domains (2) summary

cl00335
Location:6 → 152

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

pfam00334
Location:6 → 140

NDK; Nucleoside diphosphate kinase