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Tent5a terminal nucleotidyltransferase 5A [ Rattus norvegicus (Norway rat) ]

Gene ID: 300870, updated on 2-Nov-2024

Summary

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Official Symbol
Tent5aprovided by RGD
Official Full Name
terminal nucleotidyltransferase 5Aprovided by RGD
Primary source
RGD:1311381
See related
EnsemblRapid:ENSRNOG00000010240 AllianceGenome:RGD:1311381
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam46a; RGD1311381
Summary
Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. Orthologous to human TENT5A (terminal nucleotidyltransferase 5A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 85.9), Spleen (RPKM 63.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tent5a in Genome Data Viewer
Location:
8q31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (95102349..95109100, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (86222294..86229045, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (92935474..92942267, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102557561 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene uncharacterized LOC120094217 Neighboring gene inhibitor of Bruton tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations. Etokebe GE, et al. PLoS One, 2015. PMID 25884493, Free PMC Article
  2. Susceptibility to large-joint osteoarthritis (hip and knee) is associated with BAG6 rs3117582 SNP and the VNTR polymorphism in the second exon of the FAM46A gene on chromosome 6. Etokebe GE, et al. J Orthop Res, 2015 Jan. PMID 25231575
  3. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. Antoni G, et al. BMC Med Genet, 2011 Aug 2. PMID 21810271, Free PMC Article
  4. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
terminal nucleotidyltransferase 5A
Names
family with sequence similarity 46, member A
NP_001100314.1
XP_006243536.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106844.1 → NP_001100314.1  terminal nucleotidyltransferase 5A

    See identical proteins and their annotated locations for NP_001100314.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A6I1T0, D3ZH34
    Related
    ENSRNOP00000053775.2, ENSRNOT00000056937.5
    Conserved Domains (1) summary
    pfam07984
    Location:70 → 386
    NTP_transf_7; Nucleotidyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    95102349..95109100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243474.4 → XP_006243536.1  terminal nucleotidyltransferase 5A isoform X1

    Conserved Domains (1) summary
    pfam07984
    Location:51 → 367
    NTP_transf_7; Nucleotidyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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