Cldn2 claudin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cldn2provided by RGD
Official Full Name: claudin 2provided by RGD
Primary source: RGD:1560247
See related: EnsemblRapid:ENSRNOG00000054495 AllianceGenome:RGD:1560247
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560247
Summary: Predicted to enable identical protein binding activity and paracellular tight junction channel activity. Predicted to be involved in several processes, including bicellular tight junction assembly; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; and regulation of intestinal absorption. Predicted to be located in tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Orthologous to human CLDN2 (claudin 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 757.1) and Liver (RPKM 310.3) See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (108248383..108258847)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (103459870..103473794)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (111122552..111133188)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model.
Title: Investigation of the Relationship of Nesfatin-1, Adropin Levels and Claudin-2, Renalase Immunoreactivity with Kidney Function in an Experimental Hypertension Model.
Hyperglycemic levels in early stage of diabetic nephropathy affect differentially renal expression of claudins-2 and -5 by oxidative stress.
Title: Hyperglycemic levels in early stage of diabetic nephropathy affect differentially renal expression of claudins-2 and -5 by oxidative stress.
While the integrity of the urothelial barrier was preserved in the rats transduced with CLDN-2, we found that the expression of this protein in the umbrella cells initiated an inflammatory process
Title: Increased urothelial paracellular transport promotes cystitis.
We suggest that loss of claudin-2 is associated with increased natriuresis in experimental type 1 diabetic nephropathy
Title: Oxidative stress induces claudin-2 nitration in experimental type 1 diabetic nephropathy.
Chronic high-salt diet for 8 weeks in Wistar-Kyoto rats decreases claudin-2 protein expression.
Title: Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto rats.
Report downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis.
Title: Downregulation of claudin-2 expression in renal epithelial cells by metabolic acidosis.
That differential expression of claudin 2 has functional implications for bile formation.
Title: Bile duct ligation in the rat causes upregulation of ZO-2 and decreased colocalization of claudins with ZO-1 and occludin.
These results suggest that expression of claudin-2 in rodent hepatocytes may play a specific role as controlling the size of paracellular permeability in the barrier to keep bile in bile canaculi.
Title: Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions.

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General gene information

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Markers

Cldn2 (e-PCR), detects polymorphism
- UniSTS:465376

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables paracellular tight junction channel activity	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in paracellular transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of bile acid secretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of bile acid secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of intestinal D-glucose absorption	IEA Inferred from Electronic Annotation more info
involved_in regulation of intestinal D-glucose absorption	ISO Inferred from Sequence Orthology more info
involved_in regulation of intestinal lipid absorption	IEA Inferred from Electronic Annotation more info
involved_in regulation of intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: claudin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.