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Dusp7 dual specificity phosphatase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300980, updated on 27-Nov-2024

Summary

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Official Symbol
Dusp7provided by RGD
Official Full Name
dual specificity phosphatase 7provided by RGD
Primary source
RGD:735026
See related
EnsemblRapid:ENSRNOG00000010789 AllianceGenome:RGD:735026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
mkp-X
Summary
Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of MAPK cascade; peptidyl-tyrosine dephosphorylation; and signal transduction. Predicted to be active in cytosol. Orthologous to human DUSP7 (dual specificity phosphatase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 119.7), Lung (RPKM 98.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dusp7 in Genome Data Viewer
Location:
8q32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115888091..115895126)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107009369..107016404)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115069095..115076130)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC120094254 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene POC1 centriolar protein A Neighboring gene uncharacterized LOC134480228 Neighboring gene abhydrolase domain containing 14A Neighboring gene aminoacylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia. Ham JE, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26435497
  2. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. Muda M, et al. J Biol Chem, 1996 Feb 23. PMID 8626780
  3. Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. Dowd S, et al. J Cell Sci, 1998 Nov. PMID 9788880
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of DUSP6 and DUSP7 is mediated by ERK1/ERK2 activity in microglia.
    Title: Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 7
Names
MAP kinase phosphatase
dual specificity protein phosphatase MKP-X
NP_001094017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100547.1 → NP_001094017.1  dual specificity protein phosphatase 7

    See identical proteins and their annotated locations for NP_001094017.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    F1M7V9, Q63340
    Related
    ENSRNOP00000014770.5, ENSRNOT00000014770.9
    Conserved Domains (2) summary
    cd01446
    Location:55 → 186
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14643
    Location:240 → 388
    DSP_DUSP7; dual specificity phosphatase domain of dual specificity protein phosphatase 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    115888091..115895126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63340.2 GenPept UniProtKB/Swiss-Prot:Q63340

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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