Impdh2 inosine monophosphate dehydrogenase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Impdh2provided by RGD
Official Full Name: inosine monophosphate dehydrogenase 2provided by RGD
Primary source: RGD:735092
See related: EnsemblRapid:ENSRNOG00000031965 AllianceGenome:RGD:735092
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IMPD 2; IMPDH 2
Summary: Enables IMP dehydrogenase activity and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 642.9), Thymus (RPKM 626.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118135204..118139892)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109256705..109261365)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117346983..117351619)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI171562 (e-PCR)
- UniSTS:261638

RH134444 (e-PCR)
- UniSTS:217724

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IMP dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables IMP dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables IMP dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' XMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' XMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in GTP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inosine-5'-monophosphate dehydrogenase 2

Names: IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; inosine 5'-phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2

NP_954530.2

EC 1.1.1.205

XP_006243813.1

EC 1.1.1.205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199099.3 → NP_954530.2 inosine-5'-monophosphate dehydrogenase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

E9PU28

UniProtKB/TrEMBL

Q6P9U9

Related

ENSRNOP00000040635.3, ENSRNOT00000047717.6

Conserved Domains (1) summary

PLN02274
Location:15 → 514

PLN02274; inosine-5'-monophosphate dehydrogenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118135204..118139892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243751.5 → XP_006243813.1 inosine-5'-monophosphate dehydrogenase 2 isoform X1

UniProtKB/TrEMBL

Q6P9U9

Related

ENSRNOP00000108718.1, ENSRNOT00000166384.1

Conserved Domains (3) summary

PLN02274
Location:15 → 538

PLN02274; inosine-5'-monophosphate dehydrogenase

cd00381
Location:29 → 504

IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

cd04602
Location:115 → 230

CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...