U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atrip ATR interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 301014, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Symbol
Atripprovided by RGD
Full Name
ATR interacting proteinprovided by RGD
Primary source
RGD:1626390
See related
EnsemblRapid:ENSRNOG00000020670 AllianceGenome:RGD:1626390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of ATR-ATRIP complex. Orthologous to human ATRIP (ATR interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 71.5), Spleen (RPKM 66.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Atrip in Genome Data Viewer
Location:
8q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118586909..118600975, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109708440..109722511, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117797954..117811989, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene shisa family member 5 Neighboring gene three prime repair exonuclease 1 Neighboring gene U2 spliceosomal RNA Neighboring gene coiled-coil domain containing 51 Neighboring gene translation machinery associated 7 homolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATR and ATRIP: partners in checkpoint signaling. Cortez D, et al. Science, 2001 Nov 23. PMID 11721054
  2. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. Pabla N, et al. J Biol Chem, 2008 Mar 7. PMID 18162465
  3. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Maréchal A, et al. Mol Cell, 2014 Jan 23. PMID 24332808, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ATR-ATRIP complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATR-interacting protein
Names
ATR-interacting protein-like
NP_001100329.1
XP_006243829.1
XP_038937169.1
XP_038937170.1
XP_038937171.1
XP_038937172.1
XP_063121327.1
XP_063121328.1
XP_063121329.1
XP_063121330.1
XP_063121331.1
XP_063121332.1
XP_063121333.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106859.1 → NP_001100329.1  ATR-interacting protein

    See identical proteins and their annotated locations for NP_001100329.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A6I3B3, D4A4M3
    Related
    ENSRNOP00000066012.4, ENSRNOT00000073395.4
    Conserved Domains (1) summary
    cl09111
    Location:115 → 207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    118586909..118600975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265260.1 → XP_063121330.1  ATR-interacting protein isoform X4

    UniProtKB/TrEMBL
    D4A4M3

  2. XM_063265258.1 → XP_063121328.1  ATR-interacting protein isoform X2

    UniProtKB/TrEMBL
    D4A4M3

  3. XM_063265259.1 → XP_063121329.1  ATR-interacting protein isoform X3

    UniProtKB/TrEMBL
    D4A4M3, M0R950
    Related
    ENSRNOP00000103050.1, ENSRNOT00000152970.1

  4. XM_063265257.1 → XP_063121327.1  ATR-interacting protein isoform X1

    UniProtKB/TrEMBL
    D4A4M3

  5. XM_063265261.1 → XP_063121331.1  ATR-interacting protein isoform X5

    UniProtKB/TrEMBL
    D4A4M3

  6. XM_063265263.1 → XP_063121333.1  ATR-interacting protein isoform X6

  7. XM_063265262.1 → XP_063121332.1  ATR-interacting protein isoform X6

  8. XM_039081242.2 → XP_038937170.1  ATR-interacting protein isoform X6

    Conserved Domains (2) summary
    COG0419
    Location:27 → 207
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl09111
    Location:118 → 207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  9. XM_006243767.5 → XP_006243829.1  ATR-interacting protein isoform X5

    UniProtKB/TrEMBL
    D4A4M3
    Conserved Domains (1) summary
    cl09111
    Location:117 → 207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  10. XM_039081241.2 → XP_038937169.1  ATR-interacting protein isoform X6

    Conserved Domains (2) summary
    COG0419
    Location:27 → 207
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl09111
    Location:118 → 207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  11. XM_039081243.2 → XP_038937171.1  ATR-interacting protein isoform X6

    Conserved Domains (2) summary
    COG0419
    Location:27 → 207
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl09111
    Location:118 → 207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  12. XM_039081244.2 → XP_038937172.1  ATR-interacting protein isoform X7

    Conserved Domains (2) summary
    COG0419
    Location:27 → 207
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cl09111
    Location:118 → 207
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools