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Dpp9 dipeptidyl peptidase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301130, updated on 9-Dec-2024

Summary

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Official Symbol
Dpp9provided by RGD
Official Full Name
dipeptidyl peptidase 9provided by RGD
Primary source
RGD:1588575
See related
EnsemblRapid:ENSRNOG00000050748 AllianceGenome:RGD:1588575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dipeptidyl-peptidase activity and identical protein binding activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to act upstream of with a negative effect on pyroptotic inflammatory response. Predicted to be located in cell leading edge and microtubule. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DPP9 (dipeptidyl peptidase 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Lung (RPKM 53.5), Muscle (RPKM 51.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dpp9 in Genome Data Viewer
Location:
9q11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1098505..1133500, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1011347..1046337, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10846493..10882560)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene semaphorin 6B Neighboring gene TNF alpha induced protein 8 like 1 Neighboring gene uncharacterized LOC134480469 Neighboring gene myeloid-derived growth factor Neighboring gene uncharacterized LOC103693194 Neighboring gene large ribosomal subunit protein uL29-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Harstad EB, et al. Regul Pept, 2013 Sep 10. PMID 23850796
  2. Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues. Dubois V, et al. J Histochem Cytochem, 2009 Jun. PMID 19188489, Free PMC Article
  3. Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Zhang H, et al. Biochim Biophys Acta, 2015 Feb. PMID 25486458
  4. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9. Huang M, et al. Nature, 2021 Apr. PMID 33731929, Free PMC Article
  5. Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9. Tang HK, et al. FEBS Lett, 2011 Nov 4. PMID 22001206

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
    Title: Structural and biochemical mechanisms of NLRP1 inhibition by DPP9.
  2. DPP8 and DPP9 may act similarly across tissues, and that their actions might in part overlap with DPP4.
    Title: DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.
  3. We showed the expression of DPP8 and DPP9 in the testis, epididymis, and sperm.
    Title: Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_negative_effect pyroptotic inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 9
NP_001292170.1
XP_038939073.1
XP_217309.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305241.1 → NP_001292170.1  dipeptidyl peptidase 9

    See identical proteins and their annotated locations for NP_001292170.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    M0R781
    Related
    ENSRNOP00000084045.1, ENSRNOT00000104698.2
    Conserved Domains (2) summary
    pfam00326
    Location:661 → 862
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:145 → 569
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    1098505..1133500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_217309.11 → XP_217309.6  dipeptidyl peptidase 9 isoform X1

    See identical proteins and their annotated locations for XP_217309.6

    UniProtKB/TrEMBL
    A0A8I6G9M9, M0R781
    Related
    ENSRNOP00000065303.3, ENSRNOT00000075386.5
    Conserved Domains (3) summary
    COG1073
    Location:671 → 921
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam00326
    Location:720 → 921
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:204 → 628
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. XM_039083145.2 → XP_038939073.1  dipeptidyl peptidase 9 isoform X2

    UniProtKB/TrEMBL
    M0R781
    Related
    ENSRNOP00000083924.2, ENSRNOT00000099824.2
    Conserved Domains (2) summary
    COG1506
    Location:525 → 785
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00930
    Location:145 → 569
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

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