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Aars2 alanyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 301254, updated on 4-Jan-2025

Summary

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Official Symbol
Aars2provided by RGD
Official Full Name
alanyl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1310617
See related
EnsemblRapid:ENSRNOG00000025808 AllianceGenome:RGD:1310617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aarsl; AlaRS
Summary
Predicted to enable alanine-tRNA ligase activity; aminoacyl-tRNA editing activity; and peptide lactyltransferase (ATP-dependent) activity. Predicted to be involved in mitochondrial alanyl-tRNA aminoacylation and negative regulation of cGAS/STING signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8 and progressive leukoencephalopathy with ovarian failure. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 45.8), Heart (RPKM 40.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aars2 in Genome Data Viewer
Location:
9q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22981880..22993536, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15484639..15496116, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17869301..17881762, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor epsilon Neighboring gene transmembrane protein 151B Neighboring gene t-complex-associated testis expressed 1 Neighboring gene uncharacterized LOC108351892 Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene cell division cycle 5-like Neighboring gene uncharacterized LOC108351893

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy. Götz A, et al. Am J Hum Genet, 2011 May 13. PMID 21549344, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables alanine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide lactyltransferase (ATP-dependent) activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide lactyltransferase (ATP-dependent) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial alanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial alanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cGAS/STING signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alanine--tRNA ligase, mitochondrial
Names
alanyl-tRNA synthetase 2, mitochondrial (putative)
alanyl-tRNA synthetase like
alanyl-tRNA synthetase, mitochondrial
probable alanyl-tRNA synthetase, mitochondrial
XP_006244575.1
XP_006244577.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431966.1 → NP_001418895.1  alanine--tRNA ligase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    D3ZX08

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    22981880..22993536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244515.5 → XP_006244577.1  alanine--tRNA ligase, mitochondrial isoform X2

    Related
    ENSRNOP00000090578.3, ENSRNOT00000094858.3
    Conserved Domains (4) summary
    smart00863
    Location:740 → 773
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    PLN02900
    Location:34 → 978
    PLN02900; alanyl-tRNA synthetase
    cd00673
    Location:37 → 275
    AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cl08469
    Location:549 → 651
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

  2. XM_006244513.5 → XP_006244575.1  alanine--tRNA ligase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    D3ZX08
    Related
    ENSRNOP00000104177.1, ENSRNOT00000165288.1
    Conserved Domains (4) summary
    smart00863
    Location:740 → 773
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    PLN02900
    Location:34 → 1055
    PLN02900; alanyl-tRNA synthetase
    cd00673
    Location:37 → 275
    AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cl08469
    Location:549 → 651
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106891.1: Suppressed sequence

    Description
    NM_001106891.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZX08.1 GenPept UniProtKB/Swiss-Prot:D3ZX08

Gene LinkOut

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