lft1 lefty1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lft1provided by ZNC
Official Full Name: lefty1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990630-10
See related: Ensembl:ENSDARG00000019920 AllianceGenome:ZFIN:ZDB-GENE-990630-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: atv; cb73; antivin; ik:tdsubc_2b12; xx:tdsubc_2b12
Summary: Predicted to enable cytokine activity. Acts upstream of or within determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including LEFTY2 (left-right determination factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (35073981..35076377, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (35171102..35173498, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression.
Title: Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression.
Theauthors find that zebrafish lefty mutants exhibit excess Nodal signaling and increased specification of mesendoderm, resulting in embryonic lethality.
Title: Nodal patterning without Lefty inhibitory feedback is functional but fragile.
Our data do not support the reaction-diffusion model, but instead, we propose that Nodal activates signaling in a temporal window that is defined by a miR-430-mediated delay of Lft1/2 translation
Title: A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
Title: Differential diffusivity of Nodal and Lefty underlies a reaction-diffusion patterning system.
both Nodal and Bmp independently are required for lefty1 expression to assure unilateral Nodal activation and correct LR patterning
Title: Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish.
Bmp represses Nodal signaling independently of lefty1 expression and through the activity of a ligand other than Bmp4.
Title: Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.
study reports that microRNA-430 (miR-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta Nodal antagonist lefty
Title: Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.
we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription
Title: Lefty antagonism of Squint is essential for normal gastrulation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transforming growth factor beta receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in diencephalon	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lefty1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130960.1 → NP_571035.1 lefty1 precursor

Status: PROVISIONAL

Source sequence(s)

AF172089

UniProtKB/TrEMBL

Q9PW55

Related

ENSDARP00000005312.5, ENSDART00000019196.7

Conserved Domains (2) summary

pfam00688
Location:24 → 192

TGFb_propeptide; TGF-beta propeptide

cd13758
Location:265 → 350

TGF_beta_LEFTY1_2; transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins