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Stk11ip serine/threonine kinase 11 interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 301535, updated on 4-Jan-2025

Summary

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Official Symbol
Stk11ipprovided by RGD
Official Full Name
serine/threonine kinase 11 interacting proteinprovided by RGD
Primary source
RGD:1305046
See related
EnsemblRapid:ENSRNOG00000020107 AllianceGenome:RGD:1305046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Orthologous to human STK11IP (serine/threonine kinase 11 interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 59.4), Kidney (RPKM 36.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stk11ip in Genome Data Viewer
Location:
9q33
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84459733..84476521)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (77012297..77027989)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82718343..82733894)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198 Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene inhibin subunit alpha Neighboring gene solute carrier family 4 member 3 Neighboring gene uncharacterized LOC120094715

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Smith DP, et al. Hum Mol Genet, 2001 Dec 1. PMID 11741830
  2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC188315

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 11-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106922.3 → NP_001100392.2  serine/threonine-protein kinase 11-interacting protein isoform 7

    See identical proteins and their annotated locations for NP_001100392.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2, B4F7D6
    Related
    ENSRNOP00000074996.3, ENSRNOT00000080524.3
    Conserved Domains (4) summary
    sd00033
    Location:163 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234 → 274
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236 → 291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:4 → 94
    LIP1; LKB1 serine/threonine kinase interacting protein 1

  2. NM_001432885.1 → NP_001419814.1  serine/threonine-protein kinase 11-interacting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K9H2

  3. NM_001432901.1 → NP_001419830.1  serine/threonine-protein kinase 11-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2, F7F669

  4. NM_001432902.1 → NP_001419831.1  serine/threonine-protein kinase 11-interacting protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2, F7F669

  5. NM_001432903.1 → NP_001419832.1  serine/threonine-protein kinase 11-interacting protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K9H2

  6. NM_001432904.1 → NP_001419833.1  serine/threonine-protein kinase 11-interacting protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K9H2

  7. NM_001432905.1 → NP_001419834.1  serine/threonine-protein kinase 11-interacting protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2

  8. NM_001432906.1 → NP_001419835.1  serine/threonine-protein kinase 11-interacting protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2

  9. NM_001432907.1 → NP_001419836.1  serine/threonine-protein kinase 11-interacting protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2, B4F7D6

  10. NM_001432908.1 → NP_001419837.1  serine/threonine-protein kinase 11-interacting protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2

  11. NM_001432909.1 → NP_001419838.1  serine/threonine-protein kinase 11-interacting protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2

  12. NM_001432910.1 → NP_001419839.1  serine/threonine-protein kinase 11-interacting protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2

  13. NM_001432911.1 → NP_001419840.1  serine/threonine-protein kinase 11-interacting protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6AVQ2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84459733..84476521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266993.1 → XP_063123063.1  serine/threonine-protein kinase 11-interacting protein isoform X16

    UniProtKB/TrEMBL
    A0A8I6AVQ2

  2. XM_063266980.1 → XP_063123050.1  serine/threonine-protein kinase 11-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A0G2K9H2

  3. XM_063266983.1 → XP_063123053.1  serine/threonine-protein kinase 11-interacting protein isoform X4

    Related
    ENSRNOP00000092473.2, ENSRNOT00000115992.2

  4. XM_063266982.1 → XP_063123052.1  serine/threonine-protein kinase 11-interacting protein isoform X3

    UniProtKB/TrEMBL
    A0A0G2K9H2

  5. XM_063266984.1 → XP_063123054.1  serine/threonine-protein kinase 11-interacting protein isoform X5

    UniProtKB/TrEMBL
    A0A0G2K9H2

  6. XM_063266981.1 → XP_063123051.1  serine/threonine-protein kinase 11-interacting protein isoform X2

    UniProtKB/TrEMBL
    A0A0G2K9H2

  7. XM_063266985.1 → XP_063123055.1  serine/threonine-protein kinase 11-interacting protein isoform X6

    UniProtKB/TrEMBL
    A0A0G2K9H2

  8. XM_039083376.2 → XP_038939304.1  serine/threonine-protein kinase 11-interacting protein isoform X7

    UniProtKB/TrEMBL
    A0A8I6AVQ2
    Conserved Domains (3) summary
    COG4886
    Location:101 → 323
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:163 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam15904
    Location:8 → 92
    LIP1; LKB1 serine/threonine kinase interacting protein 1

  9. XM_063266986.1 → XP_063123056.1  serine/threonine-protein kinase 11-interacting protein isoform X8

  10. XM_063266987.1 → XP_063123057.1  serine/threonine-protein kinase 11-interacting protein isoform X9

    Related
    ENSRNOP00000027256.7, ENSRNOT00000027256.8

  11. XM_063266988.1 → XP_063123058.1  serine/threonine-protein kinase 11-interacting protein isoform X10

  12. XM_063266989.1 → XP_063123059.1  serine/threonine-protein kinase 11-interacting protein isoform X11

  13. XM_063266991.1 → XP_063123061.1  serine/threonine-protein kinase 11-interacting protein isoform X14

  14. XM_063266990.1 → XP_063123060.1  serine/threonine-protein kinase 11-interacting protein isoform X12

  15. XM_006245188.5 → XP_006245250.1  serine/threonine-protein kinase 11-interacting protein isoform X13

    Conserved Domains (4) summary
    sd00033
    Location:163 → 187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234 → 274
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236 → 291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:4 → 94
    LIP1; LKB1 serine/threonine kinase interacting protein 1

  16. XM_063266992.1 → XP_063123062.1  serine/threonine-protein kinase 11-interacting protein isoform X15

  17. XM_063266994.1 → XP_063123064.1  serine/threonine-protein kinase 11-interacting protein isoform X17

Nucleotide Protein Strain
Heading Accession and Version

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