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Ppp1r7 protein phosphatase 1, regulatory subunit 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301618, updated on 27-Nov-2024

Summary

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Official Symbol
Ppp1r7provided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 7provided by RGD
Primary source
RGD:1308169
See related
EnsemblRapid:ENSRNOG00000016974 AllianceGenome:RGD:1308169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sds22
Summary
Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 141.9), Thymus (RPKM 82.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r7 in Genome Data Viewer
Location:
9q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101333472..101358589)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93886068..93911198)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (99556587..100504077)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated domain-containing protein 1 pseudogene Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene protein NYNRIN-like Neighboring gene U6 spliceosomal RNA Neighboring gene anoctamin 7 Neighboring gene high density lipoprotein binding protein Neighboring gene uncharacterized LOC120094809

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei. Tran HT, et al. Biochem Cell Biol, 2002. PMID 12555814
  2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. Renouf S, et al. FEBS Lett, 1995 Nov 13. PMID 7498485
  3. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. Ceulemans H, et al. J Biol Chem, 2002 Dec 6. PMID 12226088
  4. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. Wurzenberger C, et al. J Cell Biol, 2012 Jul 23. PMID 22801782, Free PMC Article
  5. Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS. Moser K, et al. J Proteome Res, 2006 Jan. PMID 16396499

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 are found in rat liver nuclei
    Title: Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei.
  2. conserved portion of Sds22 folds into a curved superhelix; demonstrate that mutation to alanine of any of eight residues at the concave surface of this superhelix thwarts the interaction with PP1 [Sds22]
    Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105784

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 7
Names
protein phosphatase 1 regulatory subunit 22
protein phosphatase 1, regulatory (inhibitor) subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009825.2 → NP_001009825.1  protein phosphatase 1 regulatory subunit 7

    See identical proteins and their annotated locations for NP_001009825.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5HZV9
    UniProtKB/TrEMBL
    A0A8I6AM99, A6JQY6
    Related
    ENSRNOP00000081944.1, ENSRNOT00000095497.2
    Conserved Domains (3) summary
    sd00033
    Location:100 → 121
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:68 → 260
    internalin_A; class 1 internalin InlA
    cd21340
    Location:169 → 354
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    101333472..101358589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767362.4 → XP_008765584.1  protein phosphatase 1 regulatory subunit 7 isoform X1

    Conserved Domains (2) summary
    sd00033
    Location:100 → 121
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:97 → 272
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZV9.1 GenPept UniProtKB/Swiss-Prot:Q5HZV9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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