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Anks3 ankyrin repeat and sterile alpha motif domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302937, updated on 4-Jan-2025

Summary

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Official Symbol
Anks3provided by RGD
Official Full Name
ankyrin repeat and sterile alpha motif domain containing 3provided by RGD
Primary source
RGD:1305833
See related
EnsemblRapid:ENSRNOG00000003186 AllianceGenome:RGD:1305833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305833
Summary
Predicted to be located in cytoplasm. Predicted to be active in cilium. Orthologous to human ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 77.6), Adrenal (RPKM 69.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anks3 in Genome Data Viewer
Location:
10q12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11121504..11142261)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10614953..10635815)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10808780..10829507)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene septin 12 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene mahogunin ring finger 1 Neighboring gene microRNA 3568

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice. Delestré L, et al. PLoS One, 2015. PMID 26327442, Free PMC Article
  2. Anks3 alters the sub-cellular localization of the Nek7 kinase. Ramachandran H, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188091
  3. The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6. Nakajima Y, et al. Kidney Int, 2018 May. PMID 29395339
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94228

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ankyrin repeat and SAM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009676.2 → NP_001009676.1  ankyrin repeat and SAM domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001009676.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q5M9H0
    UniProtKB/TrEMBL
    A0A0G2JX10
    Conserved Domains (5) summary
    cd09519
    Location:423 → 486
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:422 → 481
    SAM; Sterile alpha motif
    cd00204
    Location:63 → 189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:106 → 199
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:69 → 99
    ANK; ANK repeat [structural motif]

  2. NM_001414337.1 → NP_001401266.1  ankyrin repeat and SAM domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JX10, A6K4Q3
    Related
    ENSRNOP00000004298.5, ENSRNOT00000004298.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    11121504..11142261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268896.1 → XP_063124966.1  ankyrin repeat and SAM domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX10, A6K4Q3
    Related
    ENSRNOP00000109824.1, ENSRNOT00000135438.1

  2. XM_006245788.3 → XP_006245850.1  ankyrin repeat and SAM domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX10
    Conserved Domains (5) summary
    cd09519
    Location:423 → 486
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:422 → 481
    SAM; Sterile alpha motif
    cd00204
    Location:63 → 189
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:106 → 199
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:69 → 99
    ANK; ANK repeat [structural motif]

  3. XM_063268897.1 → XP_063124967.1  ankyrin repeat and SAM domain-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JX10

  4. XM_039085842.2 → XP_038941770.2  ankyrin repeat and SAM domain-containing protein 3 isoform X5

  5. XM_008767484.4 → XP_008765706.1  ankyrin repeat and SAM domain-containing protein 3 isoform X6

    Conserved Domains (6) summary
    cd09519
    Location:294 → 357
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:293 → 352
    SAM; Sterile alpha motif
    cd00204
    Location:2 → 92
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11068
    Location:372 → 444
    YlqD; YlqD protein
    pfam13637
    Location:6 → 60
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:6 → 36
    ANK; ANK repeat [structural motif]

  6. XM_006245790.4 → XP_006245852.1  ankyrin repeat and SAM domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006245852.1

    UniProtKB/TrEMBL
    A0A0G2JX10
    Conserved Domains (7) summary
    cd09519
    Location:386 → 449
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    smart00454
    Location:385 → 444
    SAM; Sterile alpha motif
    cd00204
    Location:26 → 152
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam11068
    Location:464 → 536
    YlqD; YlqD protein
    pfam12796
    Location:69 → 162
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:18 → 72
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:32 → 62
    ANK; ANK repeat [structural motif]

  7. XM_039085843.2 → XP_038941771.1  ankyrin repeat and SAM domain-containing protein 3 isoform X7

    Conserved Domains (3) summary
    cd09519
    Location:260 → 323
    SAM_ANKS3; SAM domain of ANKS3 subfamily
    COG0666
    Location:6 → 65
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:5 → 36
    ANK; ANK repeat [structural motif]

RNA

  1. XR_005489787.2 RNA Sequence

  2. XR_005489786.2 RNA Sequence

  3. XR_005489788.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M9H0.1 GenPept UniProtKB/Swiss-Prot:Q5M9H0

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