Tnfrsf12a TNF receptor superfamily member 12A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfrsf12aprovided by RGD
Official Full Name: TNF receptor superfamily member 12Aprovided by RGD
Primary source: RGD:631329
See related: EnsemblRapid:ENSRNOG00000003546 AllianceGenome:RGD:631329
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fn14
Summary: Predicted to be involved in positive regulation of extrinsic apoptotic signaling pathway; regulation of angiogenesis; and regulation of wound healing. Predicted to act upstream of or within extrinsic apoptotic signaling pathway; positive regulation of axon extension; and substrate-dependent cell migration, cell attachment to substrate. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. Orthologous to human TNFRSF12A (TNF receptor superfamily member 12A). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 147.7), Muscle (RPKM 84.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (13211670..13213666, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (12707077..12709071, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (12995904..12997930, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-kappaB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin.
Title: Unraveling the biomechanistic role of Rac1/TWEAK/Fn14/NF-κB intricate network in experimentally doxorubicin-induced cardiotoxicity in rats: The role of curcumin.
High FN14 expression is associated with intracerebral hemorrhage.
Title: LncRNA Snhg3 contributes to dysfunction of cerebral microvascular cells in intracerebral hemorrhage rats by activating the TWEAK/Fn14/STAT3 pathway.
Prenatal hypoxia in rats was not associated with differences in Fn-14 protein expression in either male or female offspring. Cardiomyocytes from prenatal hypoxic male, but not female, offspring had decreased proliferation compared with controls. Activation of the TWEAK/Fn-14 pathway leads to increased proliferation but does not appear to contribute to the reduced cardiomyocyte proliferative capacity in males.
Title: The role of the tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) in offspring exposed to prenatal hypoxia.
Studies carried out in animal models of multiple sclerosis (MS) and neuroinflammation suggest TWEAK/Fn14 signaling contribute to MS pathophysiology by enhancing neuroinflammation, demyelination, and cell infiltration to the central nervous system.
Title: A further TWEAK to multiple sclerosis pathophysiology.
findings show that FGFR-1 can interact with the TNF receptor superfamily member fibroblast growth factor-inducible molecule 14 (Fn14) resulting in cardiomyocyte cell cycle reentry
Title: FGF1-mediated cardiomyocyte cell cycle reentry depends on the interaction of FGFR-1 and Fn14.
TWEAK/Fn14 axis increased cell proliferation and collagen synthesis by activating the NF-small ka, CyrillicB pathway and increasing MMP-9 activity
Title: TWEAK/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-кB pathway.
Results suggest that the cardiac TWEAK/Fn14 pathway is modified in response to myocardial injury, inflammation and pressure overload.
Title: Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats.
stress-induced regulation of the TWEAK/Fn14 axis in cardiomyocytes implies a role of the TWEAK/Fn14 pathway in cardiac remodeling
Title: FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK.
Fn14 14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization.
Title: Intraovarian tumor necrosis factor-related weak inducer of apoptosis/fibroblast growth factor-inducible-14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI281199 (e-PCR)
- UniSTS:249411

RH129279 (e-PCR)
- UniSTS:212586

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration, cell attachment to substrate	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 12A

Names: tumor necrosis factor receptor superfamily, member 12a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181086.3 → NP_851600.1 tumor necrosis factor receptor superfamily member 12A precursor

See identical proteins and their annotated locations for NP_851600.1

Status: PROVISIONAL

Source sequence(s)

BC060537

UniProtKB/TrEMBL

A6HCK9, Q80XX9

Related

ENSRNOP00000004843.5, ENSRNOT00000004842.7

Conserved Domains (2) summary

cd13413
Location:36 → 104

TNFRSF12A; CRD2 [structural motif]

pfam12191
Location:1 → 129

stn_TNFRSF12A; tumor necrosis factor receptor stn_TNFRSF12A_TNFR domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

13211670..13213666 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085851.2 → XP_038941779.1 tumor necrosis factor receptor superfamily member 12A isoform X1

Conserved Domains (1) summary

cl22855
Location:1 → 80

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)