U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302981, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Spsb3provided by RGD
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 3provided by RGD
Primary source
RGD:1310936
See related
EnsemblRapid:ENSRNOG00000015300 AllianceGenome:RGD:1310936
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tce1
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 255.3), Kidney (RPKM 212.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Spsb3 in Genome Data Viewer
Location:
10q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14411692..14417357)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13907175..13912841)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14248199..14253815)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SPRY domain-containing SOCS box protein 3
Names
T-complex expressed gene 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106988.1 → NP_001100458.1  SPRY domain-containing SOCS box protein 3

    See identical proteins and their annotated locations for NP_001100458.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A0G2JZI4, A6HCY2
    Conserved Domains (2) summary
    cd12876
    Location:139 → 321
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:311 → 347
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14411692..14417357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597221.3 → XP_017452710.1  SPRY domain-containing SOCS box protein 3 isoform X1

  2. XM_063268918.1 → XP_063124988.1  SPRY domain-containing SOCS box protein 3 isoform X3

    Related
    ENSRNOP00000101037.1, ENSRNOT00000173598.1

  3. XM_017597222.3 → XP_017452711.1  SPRY domain-containing SOCS box protein 3 isoform X6

    Related
    ENSRNOP00000020733.6, ENSRNOT00000020733.7

  4. XM_017597223.3 → XP_017452712.1  SPRY domain-containing SOCS box protein 3 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JZI4
    Related
    ENSRNOP00000112142.1, ENSRNOT00000131934.1

  5. XM_039085867.2 → XP_038941795.1  SPRY domain-containing SOCS box protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JZI4
    Conserved Domains (2) summary
    cd12876
    Location:143 → 350
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:340 → 376
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  6. XM_063268919.1 → XP_063124989.1  SPRY domain-containing SOCS box protein 3 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JZI4, D3ZVU8
    Related
    ENSRNOP00000071059.3, ENSRNOT00000077689.3

  7. XM_017597224.3 → XP_017452713.1  SPRY domain-containing SOCS box protein 3 isoform X2

  8. XM_017597227.3 → XP_017452716.1  SPRY domain-containing SOCS box protein 3 isoform X5

    Conserved Domains (2) summary
    cd12876
    Location:139 → 346
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:336 → 372
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  9. XM_039085870.2 → XP_038941798.1  SPRY domain-containing SOCS box protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JZI4
    Conserved Domains (2) summary
    cd12876
    Location:143 → 350
    SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
    cl02533
    Location:340 → 376
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

  10. XM_063268920.1 → XP_063124990.1  SPRY domain-containing SOCS box protein 3 isoform X9

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.