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Slu7 SLU7 homolog, splicing factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 303057, updated on 27-Nov-2024

Summary

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Official Symbol
Slu7provided by RGD
Official Full Name
SLU7 homolog, splicing factorprovided by RGD
Primary source
RGD:631432
See related
EnsemblRapid:ENSRNOG00000003822 AllianceGenome:RGD:631432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable pre-mRNA 3'-splice site binding activity; second spliceosomal transesterification activity; and zinc ion binding activity. Predicted to be involved in cellular response to heat; intracellular protein transport; and mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and small nuclear ribonucleoprotein complex. Orthologous to human SLU7 (SLU7 homolog, splicing factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 92.3), Spleen (RPKM 89.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slu7 in Genome Data Viewer
Location:
10q21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28406908..28425253)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (27908325..27923784)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29029556..29044919)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480673 Neighboring gene microRNA 146a Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene C1q and TNF related 2 Neighboring gene uncharacterized LOC108352074

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A day in the life of the spliceosome. Matera AG, et al. Nat Rev Mol Cell Biol, 2014 Feb. PMID 24452469, Free PMC Article
  2. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. Shomron N, et al. J Cell Sci, 2005 Mar 15. PMID 15728250
  3. Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. Shomron N, et al. Mol Biol Cell, 2004 Aug. PMID 15181151, Free PMC Article
  4. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Chua K, et al. Genes Dev, 1999 Apr 1. PMID 10197984, Free PMC Article
  5. Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene. Pei L. J Biol Chem, 1998 Feb 27. PMID 9478977

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables pre-mRNA 3'-splice site binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA 3'-splice site binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA 3'-splice site binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables second spliceosomal transesterification activity ISO
Inferred from Sequence Orthology
more info
  
enables second spliceosomal transesterification activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing, via transesterification reactions ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA splicing, via transesterification reactions ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA 3'-splice site recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-splice site recognition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small nuclear ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of small nuclear ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
pre-mRNA-splicing factor SLU7
Names
SLU7 splicing factor homolog
step II splicing factor SLU7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100550.1 → NP_001094020.1  pre-mRNA-splicing factor SLU7

    See identical proteins and their annotated locations for NP_001094020.1

    Status: VALIDATED

    Source sequence(s)
    BC062243, BC158865
    UniProtKB/Swiss-Prot
    Q6P6G1, Q80ZG5
    UniProtKB/TrEMBL
    A0A0G2K1S0, B0BNL0
    Related
    ENSRNOP00000005132.4, ENSRNOT00000005132.7
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    28406908..28425253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268963.1 → XP_063125033.1  pre-mRNA-splicing factor SLU7 isoform X1

    UniProtKB/Swiss-Prot
    Q6P6G1, Q80ZG5
    UniProtKB/TrEMBL
    B0BNL0

  2. XM_008767642.4 → XP_008765864.1  pre-mRNA-splicing factor SLU7 isoform X1

    See identical proteins and their annotated locations for XP_008765864.1

    UniProtKB/Swiss-Prot
    Q6P6G1, Q80ZG5
    UniProtKB/TrEMBL
    A0A0G2K1S0, B0BNL0
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  3. XM_063268962.1 → XP_063125032.1  pre-mRNA-splicing factor SLU7 isoform X1

    UniProtKB/Swiss-Prot
    Q6P6G1, Q80ZG5
    UniProtKB/TrEMBL
    B0BNL0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZG5.2 GenPept UniProtKB/Swiss-Prot:Q80ZG5

Gene LinkOut

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