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Pwwp2a PWWP domain containing 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 303060, updated on 4-Jan-2025

Summary

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Official Symbol
Pwwp2aprovided by RGD
Official Full Name
PWWP domain containing 2Aprovided by RGD
Primary source
RGD:1305891
See related
EnsemblRapid:ENSRNOG00000003936 AllianceGenome:RGD:1305891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305891
Summary
Predicted to enable NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of transcriptional start site selection at RNA polymerase II promoter. Predicted to be active in nucleus. Orthologous to human PWWP2A (PWWP domain containing 2A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 114.1), Lung (RPKM 80.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pwwp2a in Genome Data Viewer
Location:
10q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28654272..28696693)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (28155509..28195255)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29288060..29335425)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase inhibitory factor subunit 1, pseudogene 2 Neighboring gene ribosomal protein S2, pseudogene 35 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene uncharacterized LOC108352076 Neighboring gene adrenoceptor alpha 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis. Su L, et al. Acta Biochim Pol, 2023 Sep 6. PMID 37672715
  2. Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation. Pünzeler S, et al. EMBO J, 2017 Aug 1. PMID 28645917, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis.
    Title: Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NuRD complex binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PWWP domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127296.2 → NP_001120768.1  PWWP domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_001120768.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    B2RYP9
    Related
    ENSRNOP00000060940.1, ENSRNOT00000067013.3

  2. NM_001414339.1 → NP_001401268.1  PWWP domain-containing protein 2A isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZT71
    Related
    ENSRNOP00000080500.1, ENSRNOT00000097586.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    28654272..28696693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085909.2 → XP_038941837.1  PWWP domain-containing protein 2A isoform X3

  2. XM_039085908.2 → XP_038941836.1  PWWP domain-containing protein 2A isoform X3

  3. XM_006246139.5 → XP_006246201.1  PWWP domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A8I6GK76

  4. XM_039085901.2 → XP_038941829.1  PWWP domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    cd05835
    Location:431 → 517
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

  5. XM_039085900.2 → XP_038941828.1  PWWP domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    cd05835
    Location:431 → 517
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

  6. XM_063268965.1 → XP_063125035.1  PWWP domain-containing protein 2A isoform X1

  7. XM_039085902.2 → XP_038941830.1  PWWP domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    cd05835
    Location:431 → 517
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

  8. XM_039085904.2 → XP_038941832.1  PWWP domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    cd05835
    Location:431 → 517
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

  9. XM_039085905.2 → XP_038941833.1  PWWP domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    cd05835
    Location:431 → 517
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

  10. XM_063268966.1 → XP_063125036.1  PWWP domain-containing protein 2A isoform X1

RNA

  1. XR_010055175.1 RNA Sequence

  2. XR_010055176.1 RNA Sequence

  3. XR_005489805.2 RNA Sequence

  4. XR_010055177.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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