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Slc22a21 solute carrier family 22 (organic cation transporter), member 21 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303140, updated on 14-Nov-2024

Summary

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Official Symbol
Slc22a21provided by RGD
Official Full Name
solute carrier family 22 (organic cation transporter), member 21provided by RGD
Primary source
RGD:1561735
See related
EnsemblRapid:ENSRNOG00000069239 AllianceGenome:RGD:1561735
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Octn3
Summary
Predicted to enable carnitine transmembrane transporter activity. Predicted to be involved in carnitine transmembrane transport and monoatomic ion transport. Predicted to act upstream of or within carnitine transport. Predicted to be located in peroxisomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 127.6), Testes (RPKM 101.0) and 9 other tissues See more
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Genomic context

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See Slc22a21 in Genome Data Viewer
Location:
10q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38605665..38633376, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38104114..38133106, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39296904..39324861, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480792 Neighboring gene cyclin-dependent kinase 4, pseudogene 2 Neighboring gene solute carrier family 22 member 4 Neighboring gene PDZ and LIM domain 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: anatomical evidence for a stress hormone-sensitive dopamine clearance system. Hill JE, et al. J Chem Neuroanat, 2013 Sep. PMID 23694905
  2. Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist. Januszewicz E, et al. Int J Biochem Cell Biol, 2009 Dec. PMID 19735737
  3. Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Nagai K, et al. Arch Biochem Biophys, 2006 Aug 1. PMID 16839516
  4. OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane. Durán JM, et al. J Cell Physiol, 2005 Mar. PMID 15389639

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OCTN3 is densely expressed within the intercalated cell groups of the amygdala.
    Title: Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: anatomical evidence for a stress hormone-sensitive dopamine clearance system.
  2. a physiological role of OCTN3 as peroxisomal membrane transporter.
    Title: Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.
  3. Results demonstrate that mammalian small intestine expresses OCTN3 mRNA along the villus and that OCTN3 protein is located in the basolateral membrane.
    Title: OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carnitine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables quaternary ammonium group transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in carnitine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within carnitine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in quaternary ammonium group transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cartregulin; organic cation/carnitine transporter 2; solute carrier family 22 member 21
Names
solute carrier family 22 member 5
up-regulator of carnitine transporter, OCTN2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    38605665..38633376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087194.2 → XP_038943122.1  solute carrier family 22 member 21 isoform X2

    Conserved Domains (1) summary
    TIGR00898
    Location:52 → 357
    2A0119; cation transport protein

  2. XM_008767743.4 → XP_008765965.1  solute carrier family 22 member 21 isoform X1

    See identical proteins and their annotated locations for XP_008765965.1

    UniProtKB/TrEMBL
    A0A8I6GM55, A6HEF6, A6HEF7
    Related
    ENSRNOP00000049867.5, ENSRNOT00000041253.6
    Conserved Domains (2) summary
    cd06174
    Location:123 → 513
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12 → 523
    2A0119; cation transport protein

  3. XM_039087195.2 → XP_038943123.1  solute carrier family 22 member 21 isoform X3

    Conserved Domains (1) summary
    TIGR00898
    Location:1 → 347
    2A0119; cation transport protein

  4. XM_039087198.2 → XP_038943126.1  organic cation/carnitine transporter 2 isoform X6

    Conserved Domains (1) summary
    TIGR00898
    Location:12 → 317
    2A0119; cation transport protein

  5. XM_039087196.2 → XP_038943124.1  solute carrier family 22 member 21 isoform X4

    Conserved Domains (1) summary
    TIGR00898
    Location:12 → 353
    2A0119; cation transport protein

  6. XM_039087197.2 → XP_038943125.1  organic cation/carnitine transporter 2 isoform X5

    Conserved Domains (1) summary
    TIGR00898
    Location:12 → 322
    2A0119; cation transport protein
Nucleotide Protein Strain
Heading Accession and Version

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