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Cntrob centrobin, centriole duplication and spindle assembly protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 303240, updated on 9-Dec-2024

Summary

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Symbol
Cntrobprovided by RGD
Full Name
centrobin, centriole duplication and spindle assembly proteinprovided by RGD
Primary source
RGD:1307488
See related
EnsemblRapid:ENSRNOG00000008270 AllianceGenome:RGD:1307488
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lip8; RGD1307488
Summary
Predicted to enable protein domain specific binding activity. Predicted to be involved in centriole replication; centrosome separation; and mitotic cytokinetic process. Predicted to be active in centriole and centrosome. Used to study male infertility and male infertility due to acephalic spermatozoa. Orthologous to human CNTROB (centrobin, centriole duplication and spindle assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 42.5), Testes (RPKM 21.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cntrob in Genome Data Viewer
Location:
10q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54521338..54546569, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54022523..54047793, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55901929..55927121, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase, type B Neighboring gene guanylate cyclase 2D, retinal Neighboring gene U6 spliceosomal RNA Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3 Neighboring gene ring finger protein 227

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats. Liška F, et al. PLoS One, 2013. PMID 23577170, Free PMC Article
  2. Centrobin-tubulin interaction is required for centriole elongation and stability. Gudi R, et al. J Cell Biol, 2011 May 16. PMID 21576394, Free PMC Article
  3. Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication. Zou C, et al. J Cell Biol, 2005 Nov 7. PMID 16275750, Free PMC Article
  4. Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus. Liska F, et al. Biol Reprod, 2009 Dec. PMID 19710508, Free PMC Article
  5. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. centrobin is essential for normal patterning of the limb autopod
    Title: Overexpression of full-length centrobin rescues limb malformation but not male fertility of the hypodactylous (hd) rats.
  2. Cntrob may represent a novel candidate gene for presently unexplained hereditary forms of teratozoospermia and the "easily decapitated sperm syndrome" in humans.
    Title: Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrobin
Names
LYST-interacting protein 8
centrobin, centrosomal BRCA2 interacting protein
centrobin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134645.1 → NP_001128117.1  centrobin

    See identical proteins and their annotated locations for NP_001128117.1

    Status: PROVISIONAL

    Source sequence(s)
    EF532342
    UniProtKB/TrEMBL
    B2BKY8, B2BKZ0
    Related
    ENSRNOP00000011185.5, ENSRNOT00000011185.9
    Conserved Domains (2) summary
    PHA03247
    Location:568 → 766
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:179 → 551
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54521338..54546569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767825.4 → XP_008766047.1  centrobin isoform X2

    UniProtKB/TrEMBL
    B2BKZ0
    Conserved Domains (2) summary
    PHA03247
    Location:469 → 667
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:80 → 452
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_039085975.2 → XP_038941903.1  centrobin isoform X1

    UniProtKB/TrEMBL
    B2BKZ0
    Conserved Domains (2) summary
    PHA03247
    Location:568 → 766
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:179 → 551
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_039085976.2 → XP_038941904.1  centrobin isoform X2

    UniProtKB/TrEMBL
    B2BKZ0
    Conserved Domains (2) summary
    PHA03247
    Location:469 → 667
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:80 → 452
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_039085978.2 → XP_038941906.1  centrobin isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:285 → 483
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:1 → 283
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_063269027.1 → XP_063125097.1  centrobin isoform X3

  6. XM_063269026.1 → XP_063125096.1  centrobin isoform X3

  7. XM_039085977.2 → XP_038941905.1  centrobin isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:179 → 551
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_005489823.2 RNA Sequence

  2. XR_005489822.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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