U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nle1 notchless homolog 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303372, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Nle1provided by RGD
Official Full Name
notchless homolog 1provided by RGD
Primary source
RGD:1308301
See related
EnsemblRapid:ENSRNOG00000008287 AllianceGenome:RGD:1308301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308301
Summary
Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 55.5), Muscle (RPKM 41.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nle1 in Genome Data Viewer
Location:
10q26
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68331609..68342562, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67834059..67844771, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70250959..70261880, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene U6 spliceosomal RNA Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 myosin chaperone B Neighboring gene schlafen family member 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development. Lossie AC, et al. BMC Genet, 2012 Dec 12. PMID 23231322, Free PMC Article
  2. Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice. Yao L, et al. Blood, 2013 Nov 28. PMID 24081661, Free PMC Article
  3. The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Cormier S, et al. Mol Cell Biol, 2006 May. PMID 16611995, Free PMC Article
  4. Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells. Le Bouteiller M, et al. J Exp Med, 2013 Oct 21. PMID 24062412, Free PMC Article
  5. Notchless is required for axial skeleton formation in mice. Beck-Cormier S, et al. PLoS One, 2014. PMID 24875805, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner cell mass cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
notchless protein homolog 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127534.1 → NP_001121006.1  notchless protein homolog 1

    See identical proteins and their annotated locations for NP_001121006.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166567
    UniProtKB/TrEMBL
    B2GV82, F7FIP9
    Related
    ENSRNOP00000011320.7, ENSRNOT00000011320.8
    Conserved Domains (4) summary
    COG2319
    Location:109 → 487
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:108 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08154
    Location:19 → 79
    NLE; NLE (NUC135) domain
    sd00039
    Location:161 → 199
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    68331609..68342562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246995.5 → XP_006247057.1  notchless protein homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006247057.1

    UniProtKB/TrEMBL
    B2GV82, F7FIP9
    Conserved Domains (4) summary
    COG2319
    Location:109 → 487
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:108 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08154
    Location:19 → 79
    NLE; NLE (NUC135) domain
    sd00039
    Location:161 → 199
    7WD40; WD40 repeat [structural motif]

  2. XM_006246994.5 → XP_006247056.1  notchless protein homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006247056.1

    UniProtKB/TrEMBL
    B2GV82, F7FIP9
    Conserved Domains (4) summary
    COG2319
    Location:109 → 487
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:108 → 486
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08154
    Location:19 → 79
    NLE; NLE (NUC135) domain
    sd00039
    Location:161 → 199
    7WD40; WD40 repeat [structural motif]

  3. XM_063269084.1 → XP_063125154.1  notchless protein homolog 1 isoform X2

  4. XM_063269085.1 → XP_063125155.1  notchless protein homolog 1 isoform X2

RNA

  1. XR_010055183.1 RNA Sequence

  2. XR_010055182.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools