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Sgca sarcoglycan, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 303468, updated on 27-Nov-2024

Summary

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Official Symbol
Sgcaprovided by RGD
Official Full Name
sarcoglycan, alphaprovided by RGD
Primary source
RGD:1308062
See related
EnsemblRapid:ENSRNOG00000003998 AllianceGenome:RGD:1308062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Involved in response to denervation involved in regulation of muscle adaptation and skeletal muscle tissue regeneration. Predicted to be located in cell-cell junction; membrane raft; and sarcolemma. Predicted to be part of sarcoglycan complex. Biomarker of muscular atrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2D and muscular dystrophy. Orthologous to human SGCA (sarcoglycan alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 401.0), Muscle (RPKM 395.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sgca in Genome Data Viewer
Location:
10q26
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (80397158..80416165, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79904698..79922808, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (82770905..82785142, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase D, pseudogene 13 Neighboring gene uncharacterized LOC102556395 Neighboring gene collagen type I alpha 1 chain Neighboring gene uncharacterized LOC102557019 Neighboring gene histone linker H1 domain, spermatid-specific 1 Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene sterile alpha motif domain containing 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Long-term skeletal muscle protection after gene transfer in a mouse model of LGMD-2D. Pacak CA, et al. Mol Ther, 2007 Oct. PMID 17653106
  2. Mutational diversity and hot spots in the alpha-sarcoglycan gene in autosomal recessive muscular dystrophy (LGMD2D). Carrié A, et al. J Med Genet, 1997 Jun. PMID 9192266, Free PMC Article
  3. Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy. Roberds SL, et al. Cell, 1994 Aug 26. PMID 8069911
  4. The expression of dystrophin, alpha-sarcoglycan, and beta-dystroglycan during skeletal muscle regeneration: immunohistochemical and western blot studies. Hoshino S, et al. Acta Histochem, 2002. PMID 12086334
  5. Progressive muscular dystrophy in alpha-sarcoglycan-deficient mice. Duclos F, et al. J Cell Biol, 1998 Sep 21. PMID 9744877, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In cerebellar neurons and glial cells alpha-, beta-, gamma-, delta-, and epsilon-sarcoglycans are all expressed.
    Title: Preliminary study on sarcoglycan sub-complex in rat cerebral and cerebellar cortex.
  2. expression of alpha-sarcoglycan (Sgca)during skeletal muscle regeneration.
    Title: The expression of dystrophin, alpha-sarcoglycan, and beta-dystroglycan during skeletal muscle regeneration: immunohistochemical and western blot studies.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to denervation involved in regulation of muscle adaptation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in skeletal muscle tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dystroglycan complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of sarcoglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sarcoglycan complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-sarcoglycan
Names
adhalin
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
sarcoglycan, alpha (dystrophin-associated glycoprotein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107039.2 → NP_001100509.1  alpha-sarcoglycan isoform 1 precursor

    See identical proteins and their annotated locations for NP_001100509.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y0I5, A6HI73, D3ZDQ9
    Conserved Domains (1) summary
    pfam05510
    Location:27 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. NM_001395600.1 → NP_001382529.1  alpha-sarcoglycan isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5Y0I5
    Related
    ENSRNOP00000076943.2, ENSRNOT00000112036.2
    Conserved Domains (1) summary
    pfam05510
    Location:9 → 291
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  3. NM_001395601.1 → NP_001382530.1  alpha-sarcoglycan isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Conserved Domains (1) summary
    pfam05510
    Location:12 → 254
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    80397158..80416165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086059.2 → XP_038941987.1  alpha-sarcoglycan isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y0I5, A6HI73, D3ZDQ9
    Conserved Domains (1) summary
    pfam05510
    Location:27 → 347
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

  2. XM_039086060.2 → XP_038941988.1  alpha-sarcoglycan isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y0I5
    Related
    ENSRNOP00000005381.5, ENSRNOT00000005381.8
    Conserved Domains (1) summary
    pfam05510
    Location:20 → 340
    Sarcoglycan_2; Sarcoglycan alpha/epsilon

RNA

  1. XR_010055187.1 RNA Sequence

  2. XR_005489851.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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