Ftsj3 FtsJ RNA 2'-O-methyltransferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ftsj3provided by RGD
Official Full Name: FtsJ RNA 2'-O-methyltransferase 3provided by RGD
Primary source: RGD:1307110
See related: EnsemblRapid:ENSRNOG00000009857 AllianceGenome:RGD:1307110
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable rRNA (guanine) methyltransferase activity and rRNA (uridine-2'-O-)-methyltransferase activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and rRNA methylation. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human FTSJ3 (FtsJ RNA 2'-O-methyltransferase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 167.4), Spleen (RPKM 159.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91680735..91687475, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91180945..91187389, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94439059..94445503, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Ftsj3 (e-PCR), detects polymorphism
- UniSTS:265254

MARC_4113-4114:991938380:3 (e-PCR)
- UniSTS:231072

MARC_4113-4114:996679383:1 (e-PCR)
- UniSTS:231072

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA 2'-O-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables RNA 2'-O-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables rRNA (guanine) methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA methylation	ISO Inferred from Sequence Orthology more info
involved_in RNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA methylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, small subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

Names: 2'-O-ribose RNA methyltransferase SPB1 homolog; FtsJ RNA methyltransferase homolog 3; FtsJ homolog 3; pre-rRNA processing protein FTSJ3; protein ftsJ homolog 3; putative rRNA methyltransferase 3; rRNA (uridine-2'-O-)-methyltransferase 3

NP_001012014.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012014.1 → NP_001012014.1 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

See identical proteins and their annotated locations for NP_001012014.1

Status: PROVISIONAL

Source sequence(s)

BC086512

UniProtKB/Swiss-Prot

Q5RJT2

Related

ENSRNOP00000013295.3, ENSRNOT00000013295.8

Conserved Domains (3) summary

COG0293
Location:8 → 203

RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]

pfam07780
Location:628 → 823

Spb1_C; Spb1 C-terminal domain

pfam11861
Location:232 → 329

DUF3381; Domain of unknown function (DUF3381)