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Bptf bromodomain PHD finger transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 303617, updated on 4-Jan-2025

Summary

Official Symbol
Bptfprovided by RGD
Official Full Name
bromodomain PHD finger transcription factorprovided by RGD
Primary source
RGD:1307039
See related
EnsemblRapid:ENSRNOG00000047296 AllianceGenome:RGD:1307039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Falz
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Involved in cellular response to nerve growth factor stimulus. Located in cell body; dendrite; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Kaposi's sarcoma; alcohol dependence; and neurodevelopmental disorder with dysmorphic facies and distal limb anomalies. Orthologous to human BPTF (bromodomain PHD finger transcription factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 186.8), Spleen (RPKM 143.5) and 9 other tissues See more
Orthologs
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Genomic context

See Bptf in Genome Data Viewer
Location:
10q32.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92480007..92582485, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91980279..92082731, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (95248573..95350162, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon CCG) 2 Neighboring gene similar to human chromosome 17 open reading frame 58 Neighboring gene uncharacterized LOC120095194 Neighboring gene U11 spliceosomal RNA Neighboring gene nucleolar protein 11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
 
part_of NURF complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NURF complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleosome-remodeling factor subunit BPTF
Names
fetal Alzheimer antigen

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127535.3NP_001121007.2  nucleosome-remodeling factor subunit BPTF

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Related
    ENSRNOP00000082906.2, ENSRNOT00000119473.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    92480007..92582485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269218.1XP_063125288.1  nucleosome-remodeling factor subunit BPTF isoform X13

    UniProtKB/TrEMBL
    A0A8I6ALT2
  2. XM_039087419.2XP_038943347.1  nucleosome-remodeling factor subunit BPTF isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Conserved Domains (8) summary
    cd05509
    Location:29903090
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29282974
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21342510
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:26422777
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  3. XM_039087420.2XP_038943348.1  nucleosome-remodeling factor subunit BPTF isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLB4
    Conserved Domains (7) summary
    cd05509
    Location:29893089
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29272973
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21332509
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:26412776
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  4. XM_039087415.2XP_038943343.1  nucleosome-remodeling factor subunit BPTF isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Conserved Domains (7) summary
    cd05509
    Location:30493149
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29873033
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21932569
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:27012836
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  5. XM_039087418.2XP_038943346.1  nucleosome-remodeling factor subunit BPTF isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Conserved Domains (8) summary
    cd05509
    Location:29923092
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29302976
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21942570
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:27022837
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  6. XM_039087422.2XP_038943350.1  nucleosome-remodeling factor subunit BPTF isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Conserved Domains (8) summary
    cd05509
    Location:29923092
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29302976
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21942570
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:27022837
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  7. XM_039087414.2XP_038943342.1  nucleosome-remodeling factor subunit BPTF isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Conserved Domains (8) summary
    cd05509
    Location:30503150
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29883034
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21942570
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:27022837
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  8. XM_039087416.2XP_038943344.1  nucleosome-remodeling factor subunit BPTF isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZVH2
    Conserved Domains (8) summary
    cd05509
    Location:30503150
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29883034
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21942570
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:27022837
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  9. XM_039087423.2XP_038943351.1  nucleosome-remodeling factor subunit BPTF isoform X9

    UniProtKB/TrEMBL
    A0A8I6ALT2
    Conserved Domains (7) summary
    cd05509
    Location:29233023
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28612907
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:20672443
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:25752710
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  10. XM_039087421.2XP_038943349.1  nucleosome-remodeling factor subunit BPTF isoform X7

    UniProtKB/TrEMBL
    A0A8I6ALT2
    Conserved Domains (8) summary
    cd05509
    Location:29843084
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574713
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:29222968
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:21282504
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:26362771
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  11. XM_039087426.2XP_038943354.1  nucleosome-remodeling factor subunit BPTF isoform X18

    UniProtKB/TrEMBL
    A0A8I6ALT2
    Conserved Domains (7) summary
    cd05509
    Location:28112911
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27492795
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:19082389
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:25212656
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  12. XM_039087425.2XP_038943353.1  nucleosome-remodeling factor subunit BPTF isoform X15

    UniProtKB/TrEMBL
    A6HK68
    Conserved Domains (8) summary
    cd05509
    Location:28512951
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27892835
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:22602569
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:25832699
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  13. XM_063269221.1XP_063125291.1  nucleosome-remodeling factor subunit BPTF isoform X17

    UniProtKB/TrEMBL
    A6HK68
  14. XM_039087424.2XP_038943352.1  nucleosome-remodeling factor subunit BPTF isoform X10

    UniProtKB/TrEMBL
    A0A0G2K7N8
    Related
    ENSRNOP00000088218.2, ENSRNOT00000104873.2
    Conserved Domains (8) summary
    cd05509
    Location:29093009
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:28472893
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:22602569
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:25832699
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  15. XM_063269216.1XP_063125286.1  nucleosome-remodeling factor subunit BPTF isoform X11

    UniProtKB/TrEMBL
    A0A0G2K7N8
  16. XM_063269217.1XP_063125287.1  nucleosome-remodeling factor subunit BPTF isoform X12

    UniProtKB/TrEMBL
    A0A8I6ALT2
    Related
    ENSRNOP00000094284.2, ENSRNOT00000104176.2
  17. XM_039087427.2XP_038943355.1  nucleosome-remodeling factor subunit BPTF isoform X20

    UniProtKB/TrEMBL
    A0A0G2K7N8
    Conserved Domains (7) summary
    cd05509
    Location:26702770
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:26082654
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:20792388
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:24022518
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  18. XM_039087428.2XP_038943356.1  nucleosome-remodeling factor subunit BPTF isoform X19

    UniProtKB/TrEMBL
    A0A0G2K7N8
    Conserved Domains (8) summary
    cd05509
    Location:27972897
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    smart00571
    Location:250309
    DDT; domain in different transcription and chromosome remodeling factors
    PHA03169
    Location:574759
    PHA03169; hypothetical protein; Provisional
    cd15559
    Location:402444
    PHD1_BPTF; PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    cd15560
    Location:27352781
    PHD2_3_BPTF; PHD finger 2 and 3 found in bromodomain and PHD finger-containing transcription factor (BPTF)
    pfam03157
    Location:22062515
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam13868
    Location:25292645
    TPH; Trichohyalin-plectin-homology domain
    pfam15613
    Location:466534
    WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
  19. XM_063269219.1XP_063125289.1  nucleosome-remodeling factor subunit BPTF isoform X14

    UniProtKB/TrEMBL
    A0A0G2K7N8
  20. XM_063269220.1XP_063125290.1  nucleosome-remodeling factor subunit BPTF isoform X16

    UniProtKB/TrEMBL
    A0A0G2K7N8