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Abca8a ATP-binding cassette, subfamily A (ABC1), member 8a [ Rattus norvegicus (Norway rat) ]

Gene ID: 303638, updated on 4-Jan-2025

Summary

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Official Symbol
Abca8aprovided by RGD
Official Full Name
ATP-binding cassette, subfamily A (ABC1), member 8aprovided by RGD
Primary source
RGD:1307333
See related
EnsemblRapid:ENSRNOG00000004147 AllianceGenome:RGD:1307333
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 582.0), Muscle (RPKM 530.6) and 8 other tissues See more
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Genomic context

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See Abca8a in Genome Data Viewer
Location:
10q32.1
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95501798..95571770, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95002334..95072315, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98319480..98390484, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a, pseudogene 1 Neighboring gene ATP binding cassette subfamily A member 8 Neighboring gene ATP binding cassette subfamily A member 9 Neighboring gene ATP binding cassette subfamily A member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette sub-family A member 8-A
Names
ATP-binding cassette, sub-family A (ABC1), member 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281824.1 → NP_001268753.1  ATP-binding cassette sub-family A member 8-A

    See identical proteins and their annotated locations for NP_001268753.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZCF8
    Related
    ENSRNOP00000005665.6, ENSRNOT00000005665.8
    Conserved Domains (5) summary
    TIGR01188
    Location:493 → 787
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:1279 → 1500
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:1272 → 1591
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:27 → 416
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam13664
    Location:267 → 354
    DUF4149; Domain of unknown function (DUF4149)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    95501798..95571770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247611.5 → XP_006247673.1  ATP-binding cassette sub-family A member 8-A isoform X1

    See identical proteins and their annotated locations for XP_006247673.1

    UniProtKB/TrEMBL
    D3ZCF8
    Related
    ENSRNOP00000059943.4, ENSRNOT00000065947.6
    Conserved Domains (5) summary
    TIGR01188
    Location:493 → 787
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:1279 → 1500
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:1272 → 1591
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    pfam12698
    Location:27 → 416
    ABC2_membrane_3; ABC-2 family transporter protein
    pfam13664
    Location:267 → 354
    DUF4149; Domain of unknown function (DUF4149)

  2. XM_063269226.1 → XP_063125296.1  ATP-binding cassette sub-family A member 8-A isoform X2

RNA

  1. XR_005489862.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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