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fzd5 frizzled class receptor 5 [ Danio rerio (zebrafish) ]

Gene ID: 30364, updated on 4-Jan-2025

Summary

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Official Symbol
fzd5provided by ZNC
Official Full Name
frizzled class receptor 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-218
See related
Ensembl:ENSDARG00000025420 AllianceGenome:ZFIN:ZDB-GENE-990415-218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fz2; Fz-5; fz8c; zg02; fzd8c
Summary
Enables Wnt receptor activity. Involved in eye development and non-canonical Wnt signaling pathway. Acts upstream of or within several processes, including liver development; negative regulation of canonical Wnt signaling pathway; and swim bladder development. Predicted to be located in several cellular components, including Golgi membrane; dendrite; and perikaryon. Predicted to be active in plasma membrane. Is expressed in several structures, including endoderm; eye; gut; hematopoietic stem cell; and neural plate. Used to study coloboma. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See fzd5 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (28232522..28234444)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (28421776..28423698)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene pleckstrin homology domain containing, family M, member 3 Neighboring gene cyclin Y-like 1 Neighboring gene cAMP responsive element binding protein 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Liu C, et al. Hum Mol Genet, 2016 Apr 1. PMID 26908622, Free PMC Article
  2. Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm. Ungar AR, et al. Mech Dev, 2002 Oct. PMID 12351181
  3. Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development. Poulain M, et al. Development, 2011 Aug. PMID 21771809, Free PMC Article
  4. The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. Greenfeld H, et al. PLoS Biol, 2021 Jan. PMID 33481775, Free PMC Article
  5. A systematic survey of expression and function of zebrafish frizzled genes. Nikaido M, et al. PLoS One, 2013. PMID 23349976, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity IMP
Inferred from Mutant Phenotype
more info
  
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within non-canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swim bladder development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
frizzled-5
Names
Fz5
frizzled homolog 2
frizzled homolog 5
frizzled homolog 8c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131134.2 → NP_571209.2  frizzled-5 precursor

    See identical proteins and their annotated locations for NP_571209.2

    Status: PROVISIONAL

    Source sequence(s)
    BC163118
    UniProtKB/Swiss-Prot
    B3DIG4, B3DIG6, F6NK29
    Related
    ENSDARP00000036600.4, ENSDART00000031761.5
    Conserved Domains (2) summary
    cd07456
    Location:44 → 163
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    cd15249
    Location:235 → 546
    7tmF_FZD5; class F frizzled subfamily 5, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    28232522..28234444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3DIG4.1 GenPept UniProtKB/Swiss-Prot:B3DIG4

Gene LinkOut

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