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Mrpl58 mitochondrial ribosomal protein L58 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303673, updated on 27-Nov-2024

Summary

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Official Symbol
Mrpl58provided by RGD
Official Full Name
mitochondrial ribosomal protein L58provided by RGD
Primary source
RGD:1307942
See related
EnsemblRapid:ENSRNOG00000032780 AllianceGenome:RGD:1307942
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ict1
Summary
Predicted to enable aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific. Predicted to be involved in mitochondrial translational termination and rescue of stalled ribosome. Predicted to be located in mitochondrion; nucleoplasm; and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 339.8), Testes (RPKM 288.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl58 in Genome Data Viewer
Location:
10q32.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101145342..101151838)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100646374..100652871)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103956019..103962515)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene HID1 domain containing Neighboring gene uncharacterized LOC134480902 Neighboring gene cerebellar degeneration-related protein 2-like Neighboring gene transfer RNA arginine (anticodon CCU) 7 Neighboring gene transfer RNA arginine (anticodon CCU) 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Richter R, et al. EMBO J, 2010 Mar 17. PMID 20186120, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity, codon nonspecific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity, codon nonspecific ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational termination ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL62
Names
immature colon carcinoma transcript 1
peptidyl-tRNA hydrolase ICT1, mitochondrial
NP_001178585.1
XP_038942124.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191656.1 → NP_001178585.1  large ribosomal subunit protein mL62 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D3ZDP2
    Related
    ENSRNOP00000085915.1, ENSRNOT00000118784.2
    Conserved Domains (1) summary
    cl23917
    Location:72 → 202
    RF-1; RF-1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101145342..101151838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086196.2 → XP_038942124.1  large ribosomal subunit protein mL62 isoform X1

    Conserved Domains (1) summary
    cl29584
    Location:19 → 149
    RF-1; RF-1 domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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