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Usp36 ubiquitin specific peptidase 36 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303700, updated on 2-Nov-2024

Summary

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Official Symbol
Usp36provided by RGD
Official Full Name
ubiquitin specific peptidase 36provided by RGD
Primary source
RGD:1309937
See related
EnsemblRapid:ENSRNOG00000028255 AllianceGenome:RGD:1309937
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and histone H2B deubiquitinase activity. Predicted to be involved in several processes, including positive regulation of protein targeting to mitochondrion; protein stabilization; and regulation of macroautophagy. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 88.9), Heart (RPKM 75.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp36 in Genome Data Viewer
Location:
10q32.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103995970..104027492, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103497349..103528877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107292828..107324355, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480725 Neighboring gene cytohesin 1 Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase. DeVine T, et al. Biochem Biophys Res Commun, 2018 Jan 15. PMID 29274341, Free PMC Article
  2. Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice. Fraile JM, et al. J Biol Chem, 2018 Feb 9. PMID 29273634, Free PMC Article
  3. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Sun XX, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775507, Free PMC Article
  4. Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36. Endo A, et al. J Cell Sci, 2009 Mar 1. PMID 19208757
  5. The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. Taillebourg E, et al. Autophagy, 2012 May 1. PMID 22622177

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
    Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H2B deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleolus organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 36
Names
ubiquitin specific protease 36
NP_001100539.1
XP_038942129.1
XP_038942131.1
XP_063125312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107069.1 → NP_001100539.1  ubiquitin carboxyl-terminal hydrolase 36

    See identical proteins and their annotated locations for NP_001100539.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HL46, D3ZNQ4
    Related
    ENSRNOP00000060530.2, ENSRNOT00000064450.5
    Conserved Domains (2) summary
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:122 → 420
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    103995970..104027492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086203.1 → XP_038942131.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K033
    Related
    ENSRNOP00000071284.2, ENSRNOT00000084055.3
    Conserved Domains (2) summary
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam05109
    Location:493 → 807
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_039086201.1 → XP_038942129.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K033
    Conserved Domains (2) summary
    cd02661
    Location:121 → 421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam05109
    Location:493 → 807
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  3. XM_063269242.1 → XP_063125312.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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