Sirt7 sirtuin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sirt7provided by RGD
Official Full Name: sirtuin 7provided by RGD
Primary source: RGD:1305876
See related: EnsemblRapid:ENSRNOG00000036683 AllianceGenome:RGD:1305876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including NAD+ binding activity; NAD-dependent protein lysine deacylase activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in several processes, including chromatin remodeling; protein deacylation; and regulation of macromolecule metabolic process. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 106.5), Spleen (RPKM 93.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106394802..106401627, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105896476..105903301, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109796046..109802821, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT7 silencing by miR-152-3p confers cell apoptosis and renal functional impairment induced by renal ischaemia/reperfusion injury.
Title: SIRT7 silencing by miR-152-3p confers cell apoptosis and renal functional impairment induced by renal ischaemia/reperfusion injury.
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis.
Title: Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis.
Resveratrol Promotes Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Through miR-193a/SIRT7 Axis.
Title: Resveratrol Promotes Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells Through miR-193a/SIRT7 Axis.
the injection of BMSC-Exo-125b alleviated the pathological damages and down-regulated SIRT7 in myocardium tissues of I/R rats. BMSC-derived exosomes carrying miR-125b protected against myocardial I/R by targeting SIRT7.
Title: Bone marrow mesenchymal stem cell-secreted exosomes carrying microRNA-125b protect against myocardial ischemia reperfusion injury via targeting SIRT7.
Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/beta-catenin signaling pathway.
Title: Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway.
downregulation of miR-142-5p alleviates hypoxia-induced injury through upregulation of SIRT7.
Title: Suppression of microRNA-142-5p attenuates hypoxia-induced apoptosis through targeting SIRT7.
Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation.
Title: Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation.
Molecular studies showed that recovery was associated with the upregulation of few nuclear sirtuins that act epigenetically - Sirt 1 and 7, which were significantly attenuated in the striatum of prediabetic rats.
Title: Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats.
Age-related changes of SIRT7 gene expression in key organs of energy homeostasis are tissue dependent.
Title: Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats.
Shortterm caloric restriction may activate SIRT1 as well as SIRT24 and 7 expression in cardiomyocytes in vivo and in vitro.
Title: Short‑term calorie restriction activates SIRT1‑4 and ‑7 in cardiomyocytes in vivo and in vitro.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138691 (e-PCR)
- UniSTS:220778

D1S3698 (e-PCR)
- UniSTS:474276

RH130955 (e-PCR)
- UniSTS:214239

G73110 (e-PCR)
- UniSTS:231397

MARC_7921-7922:996688171:1 (e-PCR)
- UniSTS:231397

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein-lysine depropionylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein-lysine depropionylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K18 deacetylase activity, NAD-dependent	ISO Inferred from Sequence Orthology more info
enables histone H3K18 deacetylase activity, NAD-dependent	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutaryllysine deglutarylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutaryllysine deglutarylase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutaryllysine deglutarylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-succinyllysine desuccinylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-succinyllysine desuccinylase activity	ISO Inferred from Sequence Orthology more info
enables protein-succinyllysine desuccinylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in DNA repair-dependent chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in R-loop processing	ISO Inferred from Sequence Orthology more info
involved_in R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
involved_in homologous chromosome pairing at meiosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deglutarylation	ISO Inferred from Sequence Orthology more info
involved_in protein deglutarylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein depropionylation	ISO Inferred from Sequence Orthology more info
involved_in protein depropionylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus organizer region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-7

Names: NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7

NP_001100543.1

EC 2.3.1.286

XP_008766699.1

EC 2.3.1.286

XP_038942153.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107073.1 → NP_001100543.1 NAD-dependent protein deacetylase sirtuin-7

See identical proteins and their annotated locations for NP_001100543.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

B2RZ55, F1LQY4

UniProtKB/TrEMBL

A0A8I6A4L4

Related

ENSRNOP00000051834.3, ENSRNOT00000054951.6

Conserved Domains (2) summary

COG1196
Location:8 → 101

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:102 → 315

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

106394802..106401627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086225.2 → XP_038942153.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2

UniProtKB/TrEMBL

A0A8I6A4L4

Conserved Domains (2) summary

COG1196
Location:8 → 101

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00195
Location:114 → 234

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_008768477.4 → XP_008766699.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1

UniProtKB/TrEMBL

A0A8I6A4L4

Related

ENSRNOP00000102583.1, ENSRNOT00000152243.1

Conserved Domains (1) summary

cd01410
Location:102 → 339

SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...