cyp26a1 cytochrome P450, family 26, subfamily A, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp26a1provided by ZNC
Official Full Name: cytochrome P450, family 26, subfamily A, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-44
See related: Ensembl:ENSDARG00000033999 AllianceGenome:ZFIN:ZDB-GENE-990415-44
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb24; CYP26; P450RAI; id:ibd5061; wu:fb81e05
Summary: Enables retinoic acid 4-hydroxylase activity. Acts upstream of or within several processes, including anterior/posterior pattern specification; circulatory system development; and retinoid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including head; mesoderm; neural plate; pleuroperitoneal region; and presumptive neural plate. Used to study holoprosencephaly. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (8954761..8958355, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (8916918..8920512, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data support a model in which retinoic acid (RA) on the dorsal side of the embryo induces anterior kidney fates while posterior kidney progenitors are protected ventrally by the RA-catabolizing enzyme Cyp26a1.
Title: BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis.
Cyp26a1 expression can shape a retinoic acid gradient.
Title: Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling.
Retinoic acid (RA)-responsive genes are differentially sensitive to alterations in the RA pathway and, in particular, cyp26a1 and raraa are under a high pressure to maintain signaling integrity.
Title: Retinoic acid receptor subtype-specific transcriptotypes in the early zebrafish embryo.
In zebrafish, two Cyp26 enzymes, Cyp26a1 and Cyp26c1, are expressed in the anterior lateral plate mesoderm (ALPM) and predominantly overlap with vascular progenitors (VPs).
Title: Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm.
Zebrafish cyp26a1 promoter contains a novel retinoic acid response element that plays crucial roles in regulating its expression during early development.
Title: Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter.
Cyp26 enzymes function in endoderm to regulate pancreatic field size
Title: Cyp26 enzymes function in endoderm to regulate pancreatic field size.
2.5 k fragment underlies the regulation of the zebrafish cyp26a1 gene by retinoic acid
Title: Retinoid regulation of the zebrafish cyp26a1 promoter.
Expression of Cyp26a1 is under complex feedback and feedforward control by retinoic acid and fibroblast growth factor signaling.
Title: Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo.
cyp26 has an important role in linking the Fgf, Wnt and RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo in zebrafish
Title: Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm.
The metabolites of all-trans RA produced by Cyp26D1 were the same as that produced by Cyp26A1, which are mainly 4-hydroxy-all-trans-RA and 4-oxo-all-trans-RA.
Title: A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.

Submit: New GeneRIF Correction

General gene information

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Markers

cyp26 (e-PCR)
- UniSTS:205658

fb81e05.x1 (e-PCR)
- UniSTS:203460

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans retinoic acid 4-hydrolase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification involved in pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrial cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to vitamin A	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesodermal-endodermal cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain-hindbrain boundary development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within outflow tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoic acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoic acid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere 4 morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within rhombomere 4 morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 26A1

Names: cytochrome P450 26; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450RAI; etID42255.12; gir; giraffe; retinoic acid 4-hydroxylase; retinoic acid-metabolizing cytochrome

NP_571221.2

EC 1.14.13.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.