jupa junction plakoglobin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jupaprovided by ZNC
Official Full Name: junction plakoglobin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-991207-22
See related: Ensembl:ENSDARG00000070787 AllianceGenome:ZFIN:ZDB-GENE-991207-22
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jup; cb80; danPG; fb11b06; wu:fb11b06
Summary: Predicted to enable several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in Kupffer's vesicle development; adherens junction maintenance; and desmosome maintenance. Acts upstream of or within atrioventricular valve morphogenesis and negative regulation of Wnt signaling pathway. Located in several cellular components, including adherens junction; desmosome; and intercalated disc. Part of catenin complex. Is expressed in several structures, including EVL; ectoderm; forerunner cell group; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (11719610..11781232)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (11735989..11797611)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Although plakoglobin is clearly present during normal odontogenesis, the loss of plakoglobin does not influence tooth development.
Title: Beta-Catenin and Plakoglobin Expression during Zebrafish Tooth Development and Replacement.
knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted tail
Title: Plakoglobin has both structural and signalling roles in zebrafish development.
plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development
Title: Plakoglobin expression and localization in zebrafish embryo development.

Submit: New GeneRIF Correction

General gene information

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Markers

fl16e04.x1 (e-PCR)
- UniSTS:202013

fb11b06.x1 (e-PCR)
- UniSTS:202827

fj11d08.y1 (e-PCR)
- UniSTS:198530

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in desmosome maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IDA Inferred from Direct Assay more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in desmosome	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: junction plakoglobin a

Names: gama-catenin; gamma-catenin; plakoglobin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131177.1 → NP_571252.1 junction plakoglobin a

See identical proteins and their annotated locations for NP_571252.1

Status: PROVISIONAL

Source sequence(s)

AF099738

UniProtKB/Swiss-Prot

Q9PVF7

Related

ENSDARP00000026915.7, ENSDART00000003891.9

Conserved Domains (3) summary

smart00185
Location:330 → 370

ARM; Armadillo/beta-catenin-like repeats

cd00020
Location:379 → 498

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

sd00043
Location:382 → 407

ARM; armadillo repeat [structural motif]