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Nyap1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304376, updated on 27-Nov-2024

Summary

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Symbol
Nyap1provided by RGD
Full Name
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1provided by RGD
Primary source
RGD:1310964
See related
EnsemblRapid:ENSRNOG00000024641 AllianceGenome:RGD:1310964
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310964
Summary
Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Orthologous to human NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 61.0), Kidney (RPKM 14.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nyap1 in Genome Data Viewer
Location:
12q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24591574..24604417)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (18956192..18967624)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22025186..22037428)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481171 Neighboring gene sperm acrosome developmental regulator Neighboring gene TSC22 domain family, member 4 Neighboring gene enoyl CoA hydratase domain containing 2, pseudogene 1 Neighboring gene ArfGAP with FG repeats 2 Neighboring gene insulin receptor substrate 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, et al. EMBO J, 2011 Sep 23. PMID 21946561, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
Names
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107132.1 → NP_001100602.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

    See identical proteins and their annotated locations for NP_001100602.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J004
    Conserved Domains (2) summary
    pfam15439
    Location:15 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:574 → 835
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24591574..24604417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249144.5 → XP_006249206.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006249206.1

    UniProtKB/TrEMBL
    D3ZDP7
    Related
    ENSRNOP00000031656.5, ENSRNOT00000029041.6
    Conserved Domains (2) summary
    pfam15439
    Location:15 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:574 → 836
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  2. XM_017598325.3 → XP_017453814.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    UniProtKB/TrEMBL
    D3ZDP7
    Conserved Domains (2) summary
    pfam15439
    Location:15 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:574 → 836
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  3. XM_006249147.5 → XP_006249209.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006249209.1

    UniProtKB/TrEMBL
    D3ZDP7
    Conserved Domains (2) summary
    pfam15439
    Location:15 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:574 → 836
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

  4. XM_006249145.5 → XP_006249207.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006249207.1

    UniProtKB/TrEMBL
    D3ZDP7
    Conserved Domains (2) summary
    pfam15439
    Location:15 → 413
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:574 → 836
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
Nucleotide Protein Strain
Heading Accession and Version

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