Lrwd1 leucine-rich repeats and WD repeat domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrwd1provided by RGD
Official Full Name: leucine-rich repeats and WD repeat domain containing 1provided by RGD
Primary source: RGD:1359442
See related: EnsemblRapid:ENSRNOG00000001429 AllianceGenome:RGD:1359442
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in chromatin organization and establishment of protein localization to chromatin. Predicted to be located in chromosomal region and nuclear lumen. Predicted to be part of nuclear origin of replication recognition complex. Orthologous to human LRWD1 (leucine rich repeats and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 180.4), Spleen (RPKM 64.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26166648..26179689)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (20530035..20543078)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (23574234..23587262)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to chromatin	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to chromatin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat and WD repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013981.2 → NP_001014003.2 leucine-rich repeat and WD repeat-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A140UHX1, A0A8I6GMI0

Related

ENSRNOP00000001940.7, ENSRNOT00000001940.9

Conserved Domains (4) summary

COG4886
Location:15 → 148

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:344 → 390

7WD40; WD40 repeat [structural motif]

cl29593
Location:302 → 562

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

26166648..26179689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271287.1 → XP_063127357.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X2
XM_039089420.2 → XP_038945348.1 leucine-rich repeat and WD repeat-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6GMI0

Conserved Domains (4) summary

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

sd00039
Location:333 → 379

7WD40; WD40 repeat [structural motif]

cd21340
Location:27 → 126

PPP1R42; protein phosphatase 1 regulatory subunit 42

cl29593
Location:291 → 551

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...