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Tyw1 tRNA-yW synthesizing protein 1 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 304423, updated on 4-Jan-2025

Summary

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Symbol
Tyw1provided by RGD
Full Name
tRNA-yW synthesizing protein 1 homologprovided by RGD
Primary source
RGD:1310420
See related
EnsemblRapid:ENSRNOG00000024352 AllianceGenome:RGD:1310420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rsafd1; RGD1310420
Summary
Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; FMN binding activity; and metal ion binding activity. Predicted to be located in membrane. Orthologous to several human genes including TYW1 (tRNA-yW synthesizing protein 1 homolog). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 173.9), Kidney (RPKM 157.1) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Tyw1 in Genome Data Viewer
Location:
12q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (31968198..32054454, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26332020..26418286, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (29824990..29919240, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene calneuron 1 Neighboring gene transfer RNA serine (anticodon AGA) 21 Neighboring gene uncharacterized LOC134481284 Neighboring gene interferon induced transmembrane protein 1, pseudogene 2 Neighboring gene transmembrane protein 248 Neighboring gene Sbds, ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA wybutosine-synthesizing protein 1 homolog
Names
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase-like
radical S-adenosyl methionine and flavodoxin domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107137.1 → NP_001100607.1  tRNA wybutosine-synthesizing protein 1 homolog

    See identical proteins and their annotated locations for NP_001100607.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A0A8I6AB63, A6J0M1, B5DF48, F7FB90
    Related
    ENSRNOP00000038092.5, ENSRNOT00000038092.7
    Conserved Domains (4) summary
    cd01335
    Location:404 → 596
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PRK13762
    Location:342 → 654
    PRK13762; tRNA-modifying enzyme; Provisional
    pfam00258
    Location:76 → 227
    Flavodoxin_1; Flavodoxin
    pfam08608
    Location:586 → 649
    Wyosine_form; Wyosine base formation

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    31968198..32054454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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