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Ung uracil-DNA glycosylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 304577, updated on 27-Nov-2024

Summary

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Official Symbol
Ungprovided by RGD
Official Full Name
uracil-DNA glycosylaseprovided by RGD
Primary source
RGD:1307200
See related
AllianceGenome:RGD:1307200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables uracil DNA N-glycosylase activity. Involved in base-excision repair and negative regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 105.3), Kidney (RPKM 99.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ung in Genome Data Viewer
Location:
12q16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48145838..48154789, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42485276..42494217, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48246593..48255547, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene forkhead box N4 Neighboring gene uncharacterized LOC134481305 Neighboring gene acetyl-CoA carboxylase beta Neighboring gene legumain pseudogene Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene ubiquitin specific peptidase 30

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of uracil-DNA glycosylase induces neuronal apoptosis. Kruman II, et al. J Biol Chem, 2004 Oct 15. PMID 15297456
  2. Highly efficient base excision repair (BER) in human and rat male germ cells. Olsen AK, et al. Nucleic Acids Res, 2001 Apr 15. PMID 11292851, Free PMC Article
  3. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Imai K, et al. Nat Immunol, 2003 Oct. PMID 12958596
  4. Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues. Nilsen H, et al. Nucleic Acids Res, 2000 Jun 15. PMID 10871356, Free PMC Article
  5. Expression and activity of the DNA repair enzyme uracil DNA glycosylase during organogenesis in the rat conceptus and following methotrexate exposure in vitro. Vinson RK, et al. Biochem Pharmacol, 2002 Aug 15. PMID 12167490

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108922

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables uracil DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
involved_in base-excision repair TAS
Traceable Author Statement
more info
 PubMed 
involved_in base-excision repair, AP site formation via deaminated base removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair, AP site formation via deaminated base removal ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uracil-DNA glycosylase
NP_001013142.1
XP_008767558.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013124.1 → NP_001013142.1  uracil-DNA glycosylase

    See identical proteins and their annotated locations for NP_001013142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091211
    UniProtKB/TrEMBL
    F7F2G1, Q5BK44
    Conserved Domains (1) summary
    TIGR00628
    Location:86 → 295
    ung; uracil-DNA glycosylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    48145838..48154789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769336.4 → XP_008767558.2  uracil-DNA glycosylase isoform X1

    UniProtKB/TrEMBL
    A0A8J8YLI4, A6J209
    Conserved Domains (2) summary
    TIGR00628
    Location:93 → 302
    ung; uracil-DNA glycosylase
    cd10027
    Location:149 → 153
    UDG-F1-like; motif A [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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