Dcaf15 DDB1 and CUL4 associated factor 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcaf15provided by RGD
Official Full Name: DDB1 and CUL4 associated factor 15provided by RGD
Primary source: RGD:1304881
See related: EnsemblRapid:ENSRNOG00000006551 AllianceGenome:RGD:1304881
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304881
Summary: Predicted to enable small molecule binding activity. Predicted to be involved in protein polyubiquitination and regulation of natural killer cell activation. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF15 (DDB1 and CUL4 associated factor 15). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 101.0), Testes (RPKM 80.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40958693..40966043)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24053925..24061277)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25212469..25219803, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107162.1 → NP_001100632.1 DDB1- and CUL4-associated factor 15

See identical proteins and their annotated locations for NP_001100632.1

Status: PROVISIONAL

Source sequence(s)

CH473972

UniProtKB/TrEMBL

A6IYB1, D3ZFW6

Related

ENSRNOP00000008786.5, ENSRNOT00000008786.8

Conserved Domains (3) summary

PHA03247
Location:290 → 383

PHA03247; large tegument protein UL36; Provisional

pfam14939
Location:51 → 259

DCAF15_WD40; DDB1-and CUL4-substrate receptor 15, WD repeat

cd20913
Location:386 → 598

DCAF15-CTD; C-terminal domain of DDB1- and CUL4-associated factor 15